Article Pure but not simple by Martin Stevenson, source not given. Notes purification process developed by Speywood applied in joint research project with Royal Free succeed in isolating pure protein for Factor VIII. Genentech succeeded in synthesising the protein in a mutual collaboration deal. BTG, who were then the major Speywood shareholder, brought in new management and renegotiated the mutual collaboration deal with Genentech. Speywood gave up manufacturing rights in return for extended marketing rights in Europe and concentrated on HyateC.