Minutes of the Annual SNBTS-Haemophilia Directors Meeting Held in SNBTS Headquarter on Friday 15th May 1992 point 3.2 (i) Factor VIII Usage. Notwithstanding a slight decrease in usage during 1987 (thought to be associated with concerns related to the emerging HIV problems), the usage patterns over the last 10-15 years indicated a 10% compound increase in uptake per annum.