Letter from Jonathan Levi to Mary Brennan re problems with hepatic dysfunction in donors States that the HCV problem is complicated by the relatively high incidence of false positives with the available tests Therefore seems inappropriate to submit donors with normal biochemistry to further investigation at this stage but if they have persistent hepatic dysfunction they should be assessed by a gastroenterologist or hepatologist and a liver biopsy performed The reasons for this being the high incidence of progressive disease and the increasing evidence interferon therapy will control this