Dr Biggs stated that "Cryoprecipitate is a simple concentrate made from plasma at all Regional Transfusion Centres. Cryoprecipitate is much superior to plasma for the treatment of haemophilia A patients but the material is very variable from one sample to another and the potency cannot be known before it is used. For each dose the assumption must be made that the material is of low potency thus there is a tendency to use more material for each patient than is probably needed."