Letter, from Elizabeth Bryant, Secretary to Dr HA Townsend to Dr FE Preston, Consultant Haematologist Royal Hallamshire Hospital, regarding an attached Draft Protocol for the investigation of immunological status of Haemophiliac patients with associated liver disease. Discusses the aim of the investigation, which is to assess the immunological status of patients with haemophilia with particular attention to those who have had liver biopsies, correlate such findings, and determine the effect of Factor VIII on the immunological status.