Dr Mitchell understood from the 1978 Sheffield study in some patients liver disease was significant and progressive. He decided to restrict the use of large donor pool concentrates whenever possible in order to liver disease. Read more about Dr Mitchell understood from the 1978 Sheffield study in some patients liver disease was significant and progressive. He decided to restrict the use of large donor pool concentrates whenever possible in order to liver disease.
Dr Mitchell believed there to be a connection between the use of multi-donor factor concentrates and the development of liver disease. Read more about Dr Mitchell believed there to be a connection between the use of multi-donor factor concentrates and the development of liver disease.
Dr Mitchell used DDAVP and tranexamic acid wherever possible for mild and moderate haemophilia and for von Willebrand disorder. This was largely successfully, although it was not always adequate for moderate patients. Read more about Dr Mitchell used DDAVP and tranexamic acid wherever possible for mild and moderate haemophilia and for von Willebrand disorder. This was largely successfully, although it was not always adequate for moderate patients.
Children with severe haemophilia, were to be treated with cryoprecipitate by the Sheffield Centre until they went onto home treatment. Read more about Children with severe haemophilia, were to be treated with cryoprecipitate by the Sheffield Centre until they went onto home treatment.
Dr Mitchell acknowledged that reactions could occur but did he not recall it being a major problem. Read more about Dr Mitchell acknowledged that reactions could occur but did he not recall it being a major problem.
Dr Mitchell did not experience difficulties with obtaining sufficient quantities of cryoprecipitate or with adverse reactions to cryoprecipitate. Read more about Dr Mitchell did not experience difficulties with obtaining sufficient quantities of cryoprecipitate or with adverse reactions to cryoprecipitate.
The approach at the Sheffield Centre for adults with severe Haemophilia A, was to treat them with NHS concentrates as much as possible. Read more about The approach at the Sheffield Centre for adults with severe Haemophilia A, was to treat them with NHS concentrates as much as possible.
Whilst there were insufficient supplies so commercial concentrates were used. Dr Mitchell would have used more NHS product if it had been available. Read more about Whilst there were insufficient supplies so commercial concentrates were used. Dr Mitchell would have used more NHS product if it had been available.
When Dr Mitchell arrived at the Sheffield Centre, the majority of patients on home treatment were receiving commercial concentrate and he did not have the ability to switch them all over to NHS concentrates given the amount received. Read more about When Dr Mitchell arrived at the Sheffield Centre, the majority of patients on home treatment were receiving commercial concentrate and he did not have the ability to switch them all over to NHS concentrates given the amount received.
Dr Mitchell's policy in relation to adults with severe Haemophilia A was to adhere to one batch of one concentrate as much as possible. It took a year or so to implement this approach. Read more about Dr Mitchell's policy in relation to adults with severe Haemophilia A was to adhere to one batch of one concentrate as much as possible. It took a year or so to implement this approach.