Professor Ludlam wrote to a colleague at the Royal Infirmary that "It has recently become apparent to me that some of our patients with haemophilia have antibody to HTLV III virus." Read more about Professor Ludlam wrote to a colleague at the Royal Infirmary that "It has recently become apparent to me that some of our patients with haemophilia have antibody to HTLV III virus."
By 26 October 1984, Professor Ludlam had learned that six patients with haemophilia had developed antibody to HTLV-3; by 2 November he had received further test results relating to sixteen patients. Read more about By 26 October 1984, Professor Ludlam had learned that six patients with haemophilia had developed antibody to HTLV-3; by 2 November he had received further test results relating to sixteen patients.
Dr Tedder gave evidence that Professor Ludlam had a "clinical suspicion" which was why he had sent stored samples to Dr Tedder for testing in autumn 1984. Read more about Dr Tedder gave evidence that Professor Ludlam had a "clinical suspicion" which was why he had sent stored samples to Dr Tedder for testing in autumn 1984.
A meeting of SNBTS and haemophilia directors recorded Professor Ludlam saying cryoprecipitate was preferable for treating children because of AIDS, with Dr Hann concurring, but that a policy seemed to be emerging to use less cryoprecipitate for haemophilia A patients. Read more about A meeting of SNBTS and haemophilia directors recorded Professor Ludlam saying cryoprecipitate was preferable for treating children because of AIDS, with Dr Hann concurring, but that a policy seemed to be emerging to use less cryoprecipitate for haemophilia A patients.
At the Edinburgh Royal Infirmary, tests were undertaken using stored samples - where people were unaware their sera had been stored - both in relation to HIV testing and to Hepatitis B testing with second-generation tests. Read more about At the Edinburgh Royal Infirmary, tests were undertaken using stored samples - where people were unaware their sera had been stored - both in relation to HIV testing and to Hepatitis B testing with second-generation tests.
Professor Ludlam received the first results from an AIDS study of his and was surprised, perplexed, and puzzled as he had expected no problem with those who had been on Scottish PFC concentrate. Read more about Professor Ludlam received the first results from an AIDS study of his and was surprised, perplexed, and puzzled as he had expected no problem with those who had been on Scottish PFC concentrate.
Professor Ludlam thought the link between HIV and a deterioration in the immune system had been recognised by the virologist Professor Tedder: that AIDS could occur as a result of the side effects of impurities in the concentrates. Read more about Professor Ludlam thought the link between HIV and a deterioration in the immune system had been recognised by the virologist Professor Tedder: that AIDS could occur as a result of the side effects of impurities in the concentrates.
Professor Ludlam realised that factor concentrates not only gave rise to a potential risk of non-A, non-B infection and a real risk of HIV infection, but could also give rise to a deterioration in the immune system. Read more about Professor Ludlam realised that factor concentrates not only gave rise to a potential risk of non-A, non-B infection and a real risk of HIV infection, but could also give rise to a deterioration in the immune system.
The treating paediatricians of the San Francisco baby published a report, showing that the only possible alternative cause might be a primary immunodeficiency disorder and setting out why the clinical and laboratory findings suggested that a transmissible infectious agent had resulted in AIDS. Read more about The treating paediatricians of the San Francisco baby published a report, showing that the only possible alternative cause might be a primary immunodeficiency disorder and setting out why the clinical and laboratory findings suggested that a transmissible infectious agent had resulted in AIDS.
Professor Ludlam described his perception of non-A non-B Hepatitis as being that until the late 1980s it was seen as a "mild non-progressive condition, the first serious study on liver biopsy having been undertaken in 1985." Read more about Professor Ludlam described his perception of non-A non-B Hepatitis as being that until the late 1980s it was seen as a "mild non-progressive condition, the first serious study on liver biopsy having been undertaken in 1985."