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CSM requested the Licensing Authority to invite early applications for licence variations to permit distribution and sale of heat-treated concentrates.

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Dr Yellowlees sent a 'Dear Doctor' letter to all Regional Medical Officers saying that collections from prisons could continue despite the higher risk of Hepatitis B if all donations were subjected to more sensitive Hepatitis B tests.

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Dr Walford wrote in a DHSS minute that NANBH could "be rapidly fatal" and "lead to progressive liver damage".

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Dr Gunson warned DHSS civil servants that there could be "considerable publicity [...] concerning the safety of American Factor VIII"

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The line "no conclusive proof" first appeared in a briefing note to the Prime Minister.

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Dr Galbraith wrote to the DHSS recommending the withdrawal of US blood products due to the risk of AIDS transmission.

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The Council of Europe's Committee of Ministers' resolution recommending "all necessary steps and measures with respect to" AIDS be taken was adopted.

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The publication of the leaflet "AIDS and how it affects blood donors" was announced.

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The Expert Advisory Group on AIDS had its first meeting.

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The second leaflet, titled "AIDS; important new advice for blood donors", was made available to Regional Transfusion Centres.

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It was discovered that heat will inactivate hepatitis virus (in albumin).

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Cutter conducted experiments with heat treatment which showed Factor 9 activity could be preserved.

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Research was underway at PFC to find a way of physically removing Hepatitis B.

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Dr Harvey Alter called for viral inactivation. Calls were made by others too.

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Cutter created a task force to try to solve "the hepatitis problem".

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Behringwerke conducted experiments in heat treatment and began clinical trials.

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Hyland experimented with dry heat approach.

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Behringwerke presented its heat-treated process at the Bonn Conference.

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PFC started performing experiments on pasteurisation.

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Alpha assessed it had the "nucleus of a process that needs about three or four months' work", and applied for a FDA licence for heat-treated product in January 1983.

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