Dr Jones wrote that "Thirty years ago most haemophiliacs died of exsanguination in childhood. Today they can expect to live a normal life-span." Read more about Dr Jones wrote that "Thirty years ago most haemophiliacs died of exsanguination in childhood. Today they can expect to live a normal life-span."
Dr Peter Jones wrote that "Cryoprecipitate is now the method of choice in treating bleeding episodes in patients with haemophilia, but, when not available, adequate therapy with fresh frozen plasma is possible and can be made relatively safe." Read more about Dr Peter Jones wrote that "Cryoprecipitate is now the method of choice in treating bleeding episodes in patients with haemophilia, but, when not available, adequate therapy with fresh frozen plasma is possible and can be made relatively safe."
Dr Pool realised that plastic bags could be used in a closed, sterile system to hold separated out cryoprecipitate, which could then be stored and used by blood banks. Read more about Dr Pool realised that plastic bags could be used in a closed, sterile system to hold separated out cryoprecipitate, which could then be stored and used by blood banks.
Dr Judith Pool discovered that "cold-insoluble precipitate contains considerable quantities of the plasma antihemophilic globulin". Read more about Dr Judith Pool discovered that "cold-insoluble precipitate contains considerable quantities of the plasma antihemophilic globulin".
Until around 1974, Factor 9 contained large amounts of protein (in particular fibrinogen) other than the protein of interest (Factor 8). Fibrinogen was not readily soluble. Read more about Until around 1974, Factor 9 contained large amounts of protein (in particular fibrinogen) other than the protein of interest (Factor 8). Fibrinogen was not readily soluble.
Preparations of clotting factors derived from cows or pigs were often used for donations. Read more about Preparations of clotting factors derived from cows or pigs were often used for donations.
Freeze-dried granules could be mixed with sterile water to reconstitute what has been described as "dreadful soups and thick creamy stuff." Read more about Freeze-dried granules could be mixed with sterile water to reconstitute what has been described as "dreadful soups and thick creamy stuff."
In 1957 The Lancet was able to describe some of the development which led to the preparation of a concentrated form of Factor 8, then known as antihaemophilic factor. Read more about In 1957 The Lancet was able to describe some of the development which led to the preparation of a concentrated form of Factor 8, then known as antihaemophilic factor.
Dr Aronstam reported that where blood collects in a joint it begins to destroy parts of the lining of the joint, the synovium, which causes it to swell and then tear, in turn causing more swelling until it "resembles a sponge laden with blood". Read more about Dr Aronstam reported that where blood collects in a joint it begins to destroy parts of the lining of the joint, the synovium, which causes it to swell and then tear, in turn causing more swelling until it "resembles a sponge laden with blood".
Dr Carroll Birch described 113 patients with haemophilia, 82 of whom died before the age of 15, often from a trivial injury. Read more about Dr Carroll Birch described 113 patients with haemophilia, 82 of whom died before the age of 15, often from a trivial injury.