Although the PFL produced a small number of batches from limited donor pools using plasma from a small number of plasmapheresis donors, this product still resulted in some hepatitis transmission. Read more about Although the PFL produced a small number of batches from limited donor pools using plasma from a small number of plasmapheresis donors, this product still resulted in some hepatitis transmission.
Pool sizes for continuous thawing were between 600kg and 1,000kg, depending upon the size of freeze dryer available. Read more about Pool sizes for continuous thawing were between 600kg and 1,000kg, depending upon the size of freeze dryer available.
When the Edinburgh cohort were identified as having been infected with HTLV-3 through the use of PFC products, it was discovered that 4,000 donors had contributed to the implicated batch. Read more about When the Edinburgh cohort were identified as having been infected with HTLV-3 through the use of PFC products, it was discovered that 4,000 donors had contributed to the implicated batch.
There was an increase of around 25% from the pool sizes recorded up to 1983 after it was identified that patients from Edinburgh were infected from a batch containing 4,000 donors. Read more about There was an increase of around 25% from the pool sizes recorded up to 1983 after it was identified that patients from Edinburgh were infected from a batch containing 4,000 donors.
In a review of contemporaneous sources, pool sizes ranging from a minimum of 800 donations (200kg) to 2,200 (550kg) were used, with the size dependent on whether the smaller or the larger freeze dryer was used. Read more about In a review of contemporaneous sources, pool sizes ranging from a minimum of 800 donations (200kg) to 2,200 (550kg) were used, with the size dependent on whether the smaller or the larger freeze dryer was used.
In a review of tables on batches and the pool size from which they were made during this period, it was found that of the 27 batches listed only 10 were larger than 300 litres, and of these the highest figure was 555 litres (being 5 such batches). Read more about In a review of tables on batches and the pool size from which they were made during this period, it was found that of the 27 batches listed only 10 were larger than 300 litres, and of these the highest figure was 555 litres (being 5 such batches).
A memo from Dr Foster to John Watt and others described the specifics of a new-scale thawing tank becoming ready for use at the start of 1981. Read more about A memo from Dr Foster to John Watt and others described the specifics of a new-scale thawing tank becoming ready for use at the start of 1981.
Dr Peter Foster and Ida Dickson considered that losses in Factor 8 from having to meet quality control requirements could be reduced. Read more about Dr Peter Foster and Ida Dickson considered that losses in Factor 8 from having to meet quality control requirements could be reduced.
Dr Smith sent a memo to Dr Lane, suggesting that three tables in a report by Dr Craske, which he had presented to the working party, "offer good ammunition against the importation of U.S. plasma or its products". Read more about Dr Smith sent a memo to Dr Lane, suggesting that three tables in a report by Dr Craske, which he had presented to the working party, "offer good ammunition against the importation of U.S. plasma or its products".
Dr Craske felt that the increased usage of small pooled concentrates would help to reduce the incidence of hepatitis in the haemophilic population. Read more about Dr Craske felt that the increased usage of small pooled concentrates would help to reduce the incidence of hepatitis in the haemophilic population.