Dr Carol Kasper and Dr Shelly Kipnis considered the risks of taking blood products prepared from pooled plasma more directly, and wrote that for older children and adults who had had little exposure to blood products, especially those with mild haemophilia, single-donor products were preferable. Read more about Dr Carol Kasper and Dr Shelly Kipnis considered the risks of taking blood products prepared from pooled plasma more directly, and wrote that for older children and adults who had had little exposure to blood products, especially those with mild haemophilia, single-donor products were preferable.
Dr Joseph Garrott Allen had written that the risk of serum hepatitis from transfusions derived from prison and skid row populations was at least ten times that from the use of volunteer donors. Read more about Dr Joseph Garrott Allen had written that the risk of serum hepatitis from transfusions derived from prison and skid row populations was at least ten times that from the use of volunteer donors.
The number of donations rose to 6,000 donations from 1982 to 1985. This was eight times the number of donations used in 1975, and more than 30 times as much as Dr Biggs recorded for Oxford in relation to 1971. Read more about The number of donations rose to 6,000 donations from 1982 to 1985. This was eight times the number of donations used in 1975, and more than 30 times as much as Dr Biggs recorded for Oxford in relation to 1971.
The pools used to manufacture Factor 8 concentrate in 1983 could be almost 40 times as large as the number of donations used to treat patients at Oxford in 1971. Read more about The pools used to manufacture Factor 8 concentrate in 1983 could be almost 40 times as large as the number of donations used to treat patients at Oxford in 1971.
Dr Biggs stated "The use of freeze dried concentrate (in comparison to cryoprecipitate) did not cause a dangerous increase in episodes of jaundice". Read more about Dr Biggs stated "The use of freeze dried concentrate (in comparison to cryoprecipitate) did not cause a dangerous increase in episodes of jaundice".
Factor 8 and Factor 9 were made at the Plasma Fractionation Laboratory in Oxford. The number of donations in the mean pool size for Factor 8 in 1969 was 160 donations; in 1970 it was 192 and the same in 1971. In terms of Factor 9, larger pools were used: in 1969, 439 donations were the average, in 1970 it was 384, and in 1971, 300. Read more about Factor 8 and Factor 9 were made at the Plasma Fractionation Laboratory in Oxford. The number of donations in the mean pool size for Factor 8 in 1969 was 160 donations; in 1970 it was 192 and the same in 1971. In terms of Factor 9, larger pools were used: in 1969, 439 donations were the average, in 1970 it was 384, and in 1971, 300.
Dr Cumming explained that "after consultation with clinicians using this material, it was decided that Edinburgh should use a pool of 8 litres. The clinical opinion in Edinburgh was that a pool of this size was sensible for general use but that larger pools could be used for major surgery where large quantities were required for one patient." Read more about Dr Cumming explained that "after consultation with clinicians using this material, it was decided that Edinburgh should use a pool of 8 litres. The clinical opinion in Edinburgh was that a pool of this size was sensible for general use but that larger pools could be used for major surgery where large quantities were required for one patient."
Due to the pressure for an increase in the pool sizes used to make AHF, there was a meeting of a working party on the use of the cryoprecipitate method. Read more about Due to the pressure for an increase in the pool sizes used to make AHF, there was a meeting of a working party on the use of the cryoprecipitate method.
Dr Rosemary Biggs wrote to the MRC in advance, to say that she "also thought that we should probably consider the question of serum hepatitis and, in view of the American activities, whether or not it would be reasonable to increase the pool size for fractionation." Read more about Dr Rosemary Biggs wrote to the MRC in advance, to say that she "also thought that we should probably consider the question of serum hepatitis and, in view of the American activities, whether or not it would be reasonable to increase the pool size for fractionation."
Dr Robert Cumming and colleagues commented "Because of the risk of transmitting serum hepatitis, small-pool operation is preferable, in preparing antihaemophilic fractions." Read more about Dr Robert Cumming and colleagues commented "Because of the risk of transmitting serum hepatitis, small-pool operation is preferable, in preparing antihaemophilic fractions."