Dr Jean Grant recorded that "It has been found that a minute fraction of a millilitre of virus-laden blood was enough to cause hepatitis and it was for this reason that the production of large-pool plasma, made from the contributions of more than 300 donors, was abandoned in favour of limited pools derived from not more than ten donors." Read more about Dr Jean Grant recorded that "It has been found that a minute fraction of a millilitre of virus-laden blood was enough to cause hepatitis and it was for this reason that the production of large-pool plasma, made from the contributions of more than 300 donors, was abandoned in favour of limited pools derived from not more than ten donors."
Dr Maycock wrote that in the UK antihaemophilic globulin ("AHG") was made from donor pools of 60-100 donors, and described a "paucity of reports of hepatitis" associated with this. Read more about Dr Maycock wrote that in the UK antihaemophilic globulin ("AHG") was made from donor pools of 60-100 donors, and described a "paucity of reports of hepatitis" associated with this.
A working party on human antihaemophilic globulin decided "it was considered inadvisable, when planning increased production, to increase the plasma pool volume much above this size (30-40 litres in volume), unless further observations indicated that the risk was smaller than the present series of cases suggested." Read more about A working party on human antihaemophilic globulin decided "it was considered inadvisable, when planning increased production, to increase the plasma pool volume much above this size (30-40 litres in volume), unless further observations indicated that the risk was smaller than the present series of cases suggested."
Dr Maycock and Leon Vallet proposed to "retain the present pool size (30L) because of the risk of transmitting serum hepatitis." Read more about Dr Maycock and Leon Vallet proposed to "retain the present pool size (30L) because of the risk of transmitting serum hepatitis."
Dr Peter Wolf commented "The risk of contamination of blood with the virus of infective hepatitis limits a single fractionation batch to a donor pool of 50" but "Human A.H.F. concentrate, produced in this way at multiple centres throughout the country, could provide sufficient to treat all the known classical haemophiliacs in Great Britain." Read more about Dr Peter Wolf commented "The risk of contamination of blood with the virus of infective hepatitis limits a single fractionation batch to a donor pool of 50" but "Human A.H.F. concentrate, produced in this way at multiple centres throughout the country, could provide sufficient to treat all the known classical haemophiliacs in Great Britain."
Pools used to prepare antihemophilic factor were 14-22 litres in size. This amounted to the use of pools made from a maximum of 90-110 donations. There was said to be no "contra-indications to the prolonged or repeated use of the product." Read more about Pools used to prepare antihemophilic factor were 14-22 litres in size. This amounted to the use of pools made from a maximum of 90-110 donations. There was said to be no "contra-indications to the prolonged or repeated use of the product."
A study by Biggs in the British Journal of Haematology described the process of preparing Factor 9 concentrate using 45-50 litres of plasma. Read more about A study by Biggs in the British Journal of Haematology described the process of preparing Factor 9 concentrate using 45-50 litres of plasma.
In a letter to Dr Maycock, Dr Drummond stated that he did not think it was justifiable to continue to issue large pool plasma which had a 10% incidence of homologous serum jaundice as opposed to 1% for small pools, and that were a case of this to go to court it would not be justifiable since it was practicable to make small pools. Read more about In a letter to Dr Maycock, Dr Drummond stated that he did not think it was justifiable to continue to issue large pool plasma which had a 10% incidence of homologous serum jaundice as opposed to 1% for small pools, and that were a case of this to go to court it would not be justifiable since it was practicable to make small pools.
A study of British Army records concluded that plasma was more icterogenic than whole blood and one reason for this was likely because one bottle of plasma came from a pool to which many donors contributed. Read more about A study of British Army records concluded that plasma was more icterogenic than whole blood and one reason for this was likely because one bottle of plasma came from a pool to which many donors contributed.
In a letter to a Dr Lehane, Dr Maycock stated that all large pool plasma should be replaced with small pool plasma and that the large pool plasma could be diverted to Liverpool so that the small pools could be examined for infectivity. Read more about In a letter to a Dr Lehane, Dr Maycock stated that all large pool plasma should be replaced with small pool plasma and that the large pool plasma could be diverted to Liverpool so that the small pools could be examined for infectivity.