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An inventory for Alpha UK showed that just under 25% of its current stocks remained non-heat-treated at the start of September 1985.

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The response by UK doctors to steps taken in the US was mixed. Dr Harris reported that Dr Rotblat "had been summoned to the Chief Medical Officer of the DHSS to answer questions concerning our product recall and discussions held in March concerning potential problems with Armour Factorate HT."

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Cutter had shown a hepatitis rate from heat treated products of 20% in "virgin or near-virgin" patients in studies in Bonn and Freiburg, and Hyland had a rate of 80% in a multi-centre study conducted by Dr Pier Mannucci.

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The first batch of Cutter product, Koate HT, which was made from 100% tested plasma was shipped to the UK in January/February 1986.

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An internal Cutter memo recorded that although "Cutter will only sell 100% screened material" nonetheless "some Centre Directors are happy to use up their existing stock of unscreened Koate HT."

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Dr Rotblat was intending to discuss the matter of seroconversion further with Robert Christie of Armour to ascertain if he had any possible new evidence.

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In a paper on the safety of heat-treated Factor 8 prepared by Dr Rotblat, it was reported there were two cases of seroconversion after treatment with heat-treated Factorate from a batch known to contain a donor who had AIDS.

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Gilbert C et al published an article in "The Lancet" describing a case of seroconversion of AIDS in a person with mild haemophilia after administration of high doses of heat treated Factor 8 concentrate.

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Professor Arthur Bloom wrote to the DHSS to urge that heat-treated products be licensed so as to be freely available.

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Professor Bloom was assured by the DHSS that prompting "the appropriate manufacturers" to apply for abridged product licences to ensure the supply of heat-treated product was a "high priority item".

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The meetings of the AIDS group of UKHCDO directors agreed to recommend that only heat-treated product should be used thereafter.

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EAGA's discussion of cases found the Lewisham patient (referred to in the minutes as the patient with mild haemophilia who had not received treatment since 1980) could not be explained by late seroconversion.

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The Biologicals Sub-Committee of the Committee on Safety of Medicines decided that there was "insufficient evidence for action to be taken on any specific product" but that "close surveillance should be maintained on the two possible cases of HTLV-III transmission in recipients of Armour material."

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Dr Jones wrote to colleagues enclosing a copy of his conference paper and explaining his decision to present the information about possible seroconversions at the conference.

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The CBLA announced that they planned to heat all Factor 8 manufactured at BPL/PFL from April 1985.

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The record of the 27 November meeting of the Working Group on AIDS described it as having gone "reasonable [sic] well"; whereas other reports expressed a significantly different viewpoint.

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Dr Harris said of heat treatment of Factor VIII in a meeting of the Working Group on AIDS that: "although there is not yet the evidence to guarantee that this is satisfactory; the view was nevertheless unanimous that it should be done."

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Professor Bloom issued a questionnaire to haemophilia centre directors. It asked whether (and to what extent) they were still using non-heat-treated product. At a meeting of the AIDS group of UKHCDO directors his analysis was discussed.

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Dr Harris of Armour described Dr Rotblat as "a valuable ally at the moment" and recorded that "I am now obliged to report Dr Whitmore's patient who sero-converted following treatment with Factorate HT Y69402 to her as Dr Whitmore has confirmed that the patient remains HTLV-III positive."

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A report prepared by Dr Rotblat for the CMO repeated Armour's claim that they had done viral inactivation studies "and shown good inactivation".

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