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In a letter from Dr Rizza to Dr Alison Smithies, the DHSS stated that BPL would start releasing 8Y prepared from tested donors from the middle of August, and by the end of September, if not sooner, all NHS Factor 8 would be from tested donors.

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Peter Jones wrote to Medical Assessor, The Committee on Safety of Medicines urging that any material that had not been collected in low risk areas, been individually donor tested and heat treated in an approved manner, should be withheld, at the very least from seronegative people.

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In March 1984, BPL products made by combining a "small pool" approach and heat treatment were used for the first time.

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Preliminary results on the heat treatment of PFC Factor 8 concentrate were published.

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A survey published in the "British Medical Journal" showed that a fifth of centres were using heat treated commercial Factor 9.

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The CBLA agreed to finance the trial of 8CRV.

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PFC routinely issued heat-treated Factor 9 from August 1985.

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Dr Foster stated that observations confirmed that Factor 8 activity could be destroyed even by modest increases in temperature, and at the time it seemed inconceivable that Factor 8 could be heat treated at a temperature high enough to eliminate the risk of hepatitis transition.

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Scotland produced DEFIX and similarly to BPL/PFL's 9A product, there were worries It could lead to thrombosis in some cases.

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PFC Liberton first issued Factor 8 from plasma tested for HIV/HTLV-3 antibody in February 1986.

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Dr Joel Spero stated that a major effort was necessary to develop a 'clean' product rapidly, in order to treat the next generation of haemophilia patients.

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Dr Foster reported to the directors of SNBTS at their meeting that the Factor 8 concentrate being issued were derived from unscreened plasma, but it was anticipated the position would change soon.

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Immuno, Vienna concentrated on a virucidal process to inactivate hepatitis viruses. This was announced to many of the UKHCDO Directors and Dr Craske at a meeting, and it was said the early results had been successful.

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Dr Perry wrote to five Scottish regions and Belfast to tell them on 10 or 11 December they would be supplied with sufficient heat-treated product to cover a month and continuous supply would be made thereafter in sufficient quantities to enable non-heat-treated product to be recalled.

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Scotland was ahead of England and had started to heat Factor 8 stocks in a way which would inactivate HTLV-3 from 18 November 1984.

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Although a universal Hepatitis B vaccine only began in the UK in 2017, a few children with haemophilia were vaccinated in the early 1980s.

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It was reported that there was a higher risk of hepatitis from commercially obtained blood than from blood from unpaid donors.

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Alpha had a 22% level of hepatitis infection from commercial products at the start of 1986.

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In February 1986 the possibility that Factorate HT, Armour's heat-treated Factor 8 product, might have caused HIV transmission became widespread knowledge.

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Alter et al in the article "The Ausria Test: Critical Evaluation of Sensitivity and Specificity" concluded that "the single most significant measure for the reduction of posttransfusion hepatitis is the total exclusion of the commercial donor."

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