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At a SNBTS Directors' meeting it was stated that it was believed that the Birmingham RTC was about to begin routine testing of ALT and anti-HBc.

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At a meeting of SNBTS and Haemophilia directors, Dr Forrester said that a decision on the introduction of Non-A Non-B Hepatitis screening would wait until the outcome of the multi-centre study. Dr McClelland and Professor Cash "considered the delay unjustifiable."

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It was agreed that a questionnaire on the use of Non-A Non-B Hepatitis surrogate screening in different countries would be circulated prior to the next European Health Committee meeting.

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Dr Gunson shared the replies to the questionnaire on the use of surrogate screening for Non-A Non-B Hepatitis in different countries with the Advisory Committee on the Virological Safety of Blood.

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At a meeting of the Steering Committee on Multi-Centre Study of ALT and anti-HBc Screening of Blood Donations, the study protocol was discussed in detail and it was anticipated that screening would begin on 1 September 1988.

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At a meeting of Regional Transfusion Directors it was noted that the results of the ALT multi-centre study were not expected before late spring 1989.

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At meeting of SNBTS directors, Dr Gunson explained that Chiron had agreed to test 1,000 randomly selected samples from the multi-centre study. The Scottish transfusion directors confirmed they would not start surrogate testing unless and until it was supported by the Department of Health and SHHD,

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At the first meeting of the ACTTD it was agreed that no recommendation to introduce ALT testing would be made until the multi-centre study was completed. It was noted that surrogate screening might be introduced in response to the position taken in other countries in relation to plasma products.

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Dr Gunson explained to the NBTS/CBLA Liaison Committee the NBTS's view that the introduction of ALT testing was unnecessary. It was agreed that the issue
would be considered further at another meeting

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At the first ACVSB meeting a paper on surrogate testing for NANBH was considered, although a final decision would have to await the results of further research.

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A paper provided to ACVSB members explained it was too early to report on the UKBTS study into surrogate testing and conclusions would not be drawn until the result of the Chiron tests were known.

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It was agreed at the meeting of the Advisory Committee on the Virological Safety of Blood that the use of Chiron or surrogate testing for HCV would be influenced by Chiron data once released.

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Dr Gunson recommended that the routine introduction of non-specific tests for HCV should be deferred unless necessary to acquire product licences.

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The Advisory Committee on Transfusion Transmitted Diseases agreed that Dr Gunson's report, both Chiron's test (now called the anti-HCV test) and NANBH surrogate screening, should be used as the basis for a paper to be submitted to the ACVSB.

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Dr Gunson presented a summary of results of the study on Alanine Amino-Transferase and Hepatitis B Core Screening of Blood Donations for an ACVSB meeting.

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The ACVSB felt that there was no case for using surrogate tests for Non-A Non-B Hepatitis.

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A report for a multi-centre study on Non-A Non-B Hepatitis surrogate screening was completed.

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Dr Kernoff wrote to Dr Colvin describing Non-A Non-B Hepatitis as "a serious disease with long-term consequences".

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Alter et al published a paper titled 'The Chronic Sequelae of Non-A Non-B Hepatitis B' in the Annals of Internal Medicine journal.

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A study by Ware et al titled 'Etiology of liver disease in renal transplant patients' reported that infection with NANBH accounted for much of serious, often fatal, complications of renal transplantation.

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