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The Expert Group on the Treatment of Haemophilia decided the initial aim would be to provide anti-haemophilic globulin concentrate from 250,000 donations.

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An MRC report noted that to meet the requirements of Factor 8 the total material needed was likely to be 547,540-750,000 blood donations per annum.

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The DHSS wrote to regional administrators that the immediate need for AHG concentrate, the cost of commercial alternatives, and the potential threat to the voluntary donor system meant achieving self-sufficiency was "of the greatest importance".

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Dr Owen announced the Government's committment to self-sufficiency and the allocation of special finance in furtherance of this goal.

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Dr Bidwell calculated that between 970,920 and 1,213,650 donations would need to be devoted to plasma supply to produce the required amount of Factor 8.

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At a meeting of the Expert Group on the Treatment of Haemophilia, Dr Biggs advanced an estimate of a total requirement of 40 million iu of Factor 8 across the UK.

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Dr Lane said he was unwilling to enter into an agreement with PFC to have regular quantities of plasma fractionated in Edinburgh.

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The Trends Working Group reported that UK capability was less than half what was required and that considerable further investment in collecting, testing, processing and premises was needed to meet targets.

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Minister of Health Roland Moyle recognised that the commitment to self-sufficiency had "not yet" been met.

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BPL was inspected by the Medicines Inspectorate who produced a damning report calling for urgent action.

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Ministers instructed officials to begin work on planning and designing a new BPL.

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By this time, some 90% of the blood products used in Scotland were manufactured in Edinburgh, making Scotland virtually self-sufficient.

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The Treasury approved the redevelopment of BPL at a cost of £22.6 million.

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The redevelopment of BPL was scheduled for completion at a revised cost estimate of £60 million.

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A paper presented to MRC Jaundice Committee on Prevention of Homologous Serum Jaundice recommended restricting the size of pools.

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Representatives of the MRC Jaundice Committee and the Ministry of Health met and decided to use small pools.

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In the leading textbook on blood transfusion in clinical medicine Professor Patrick Mollison wrote the use of large pool plasma had been abandoned.

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WHO Expert Committee on Hepatitis made recommendations of methods that should be adopted to reduce the risk of spreading serum hepatitis, including control of pool size.

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A Ministry of Health, MRC and Department of Health for Scotland study showed restricting the size of plasma pools greatly reduces the incidence of jaundice.

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BPL had plans to move to a pool size of 250 litres (thus some 1,250 donations).

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