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The judgment in the case of A and Others discussed testing in respect of non-A non-B Hepatitis/Hepatitis C and how raised ALT levels could suggest an abnormality of liver function; but also that it was only a possible indicator of hepatitis, not a test for it.

Published on: 06 August, 2024

The judgment in A and Others stated that those responsible for blood transfusion in the UK did not support and did not introduce surrogate tests such as tests for raised ALT in the UK, notwithstanding their adoption in the US and other places.

Published on: 06 August, 2024

The World in Action documentary, Blood Money, described how plasma centres on skid row were booming with donors who were paid for selling up to half a litre of plasma up to twice a week. Many of these donors lied about their health, or about drinking the night before, and doctors did not always carry checks for drug users.

Published on: 06 August, 2024

This journal article in describing the history of blood transfusion in the UK discussed how the Blood Transfusion Research Committee realised that there was a potential danger in transfusing pooled human plasma, as in 1937 several people had died of acute hepatic necrosis following the injection of pooled plasma.

Published on: 06 August, 2024

A study by Truelove et al concluded a sufficient explanation for delayed jaundice associated with blood transfusion and a difference in plasma versus whole blood transfusion in that that one bottle of blood came from a single donor while one bottle of plasma came from a pool to which many donors contributed.

Published on: 06 August, 2024

An article in The British Medical Journal stated that when plasma from relatively large pools was used, the incidence of hepatitis could reach an alarming figure of 11.9%, but if the plasma pool was prepared from less than 10 bottles, the figure fell to 1.3%.

Published on: 06 August, 2024

Mollison's book on "Blood Transfusion in Clinical Medicine" described why large pools were abandoned in favour of small pools was because it greatly reduced the incidence of hepatitis.

Published on: 06 August, 2024

The Department of Health and Social Security ("DHSS") appointed an advisory group which advised in July 1971 that the regional transfusion centres should begin testing "at the earliest possible date"; the DHSS accepted the recommendation.

Published on: 06 August, 2024

In a written answer on serum hepatitis, it was noted that all regional hospital boards would begin testing for the presence of the Australia antigen.

Published on: 06 August, 2024

A memo from the DHSS showed that the DHSS would start testing for Hepatitis B as soon as possible.

Published on: 06 August, 2024

In June 1942 the UK Ministry of Health reported an outbreak of jaundice amongst children given measles convalescent serum from a particular batch (K60).

Published on: 06 August, 2024

A review of previous reports of post-transfusion hepatitis began with the words: "It must now be recognised that under certain circumstances at present undefined hepatic necrosis may follow the parenteral administration of human blood products."

Published on: 06 August, 2024

In a note from Dr Panton to Dr Bradley, a joint sub-committee of the Jaundice Committee and the Blood Transfusion Research Committee of the Medical Research Council was proposed to deal specifically with post-transfusion hepatitis.

Published on: 06 August, 2024

The meeting of the Jaundice Committee showed that post-transfusion or serum hepatitis was well recognised by 1944.

Published on: 06 August, 2024

Bradley et al, in their article 'An Episode of 'Homologous Serum Jaundice' in The British Medical Journal, noted that the risk of transfusion-related hepatitis was sufficiently serious to set up a sub-committee in 1945 dealing solely with post-transfusion hepatitis.

Published on: 06 August, 2024

In a letter from Dr Maycock to Dr Robb-Smith, it was noted that users of plasma must be told that it was a potentially lethal fluid which should be used with discretion.

Published on: 06 August, 2024

In a note from Dr Maycock to Miss Long, the need to tell patients that they were at risk of contracting hepatitis via transfusion was noted.

Published on: 06 August, 2024

In a letter from J H Keidan Solicitors to Miss Long, the need to tell patients they were at risk was advised by solicitors.

Published on: 06 August, 2024

It was noted in MacCallum's Homologous Serum Hepatitis Proceedings of the Royal Society of Medicine that pooling plasma from a larger pool of donors would increase the risk of contracting hepatitis.

Published on: 06 August, 2024

Dr Maycock was concerned that a legal case regarding a lady that had died from hepatitis-related transfusion would lead to the plasma production being stopped.

Published on: 06 August, 2024

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