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It was stated that the "The biological roles of Factors 8 and 9 are closely related...and so the clinical picture that is caused by these deficiencies is near identical."

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An application for renewal of product licence Proplex Factor IX Complex was made from Travenol Laboratories

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Proplex Factor IX Complex (Human) was granted a product licence

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Authority was given for the grant of a product licence for Proplex Factor IX Complex

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Table provided Protein Fraction Centre licences updates and renewals

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Part II Licensing granted authority for products including 'dried human antihemophilic fraction' and 'dried human factor IX fraction'

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As the 1970s progressed, home therapy with Factor 9 concentrates became a feature of the treatment of people with Haemophilia B

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Newsletter

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By 1979, the issue of chronic hepatitis dominated everyone's lives.

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Dr Forbes said that by 1983, doctors were already starting to observe patients to see if there were early signs of AIDS.

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Dr Forbes acknowledged in 1983 that there was the potential for locally sourced donors to bring contaminated blood with HIV into the donor pool.

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The Belfast Haemophilia Centre was established in 1958 but until 1981 it was included in the Oxford supra-region.

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At the meeting of the Haemophilia reference centre directors held on 14 September 1981, it was noted that the annual returns for 1980 showed that the amount of Factor VIII concentrates used, especially commercial materials, had again increased.

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Dr Elizabeth Mayne became director of the Belfast Haemophilia Centre.

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Dr Mayne describing the history of haemophilia care in Northern Ireland, described patients as being "ecstatic" with the advent of cryoprecipitate which was "revolutionary".

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Hemofil was the commercial concentrate used in Belfast Haemophilia Centre

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Throughout the 1970s liver function tests performed on patients at Belfast Haemophilia Centre showed persistent abnormal liver function.

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According to Dr Mayne, there was increasing evidence that NANB hepatitis was not as benign as had been thought but could progress from chronic persistent hepatitis to cirrhosis.

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Dr Mayne enquired with Dr Craske as to the relevance to haemophilia "he reminded us that the individuals cited in the paper were known to maintain their lifestyle by being paid blood donors, as was documented in the World in Action (1975) programme."

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Dr Mayne noted manifest advantages of Factor VIII concentrates over cryoprecipitate, such as accurate calculated dosage to be given in small volume, associated with a decreased chance of clinical side effects.

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