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Dr Gunson said: "I should say that, despite the concerns expressed (in particular by Dr Contreras at the North London RTC), this approach gave rise to no serious difficulties in practice, and I do not believe that it had any consequences for the implementation date eventually achieved."

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Dr Pickles wrote to John Canavan: "Dr Gunson has been in touch with all the RTCs about starting dates for HCV testing. There are all sorts of problems still, eg exact choice of test, supplies of this, confirmatory testing arrangements, training etc etc."

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Dr Gunson stated that he doubted "whether the Newcastle and Glasgow Centres have the laboratory capability to carry out the additional work now proposed."

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The minister was informed that it was unlikely that routine screening could be introduced before 1 April 1991. In fact, the date of introduction slipped from April to July to September.

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Dr Gunson informed the Department of Health: "the other major competitor company feels disadvantaged, and has also caused problems in Scotland."

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Dr Gunson included a briefing note in case of press inquiries, which stressed the importance of selecting tests with proven reliability.

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Dr Gunson presented the preliminary report on the UKBTS study of surrogate and Chiron testing which noted: "The Chiron test had been used in first time recipients of Factor 8Y. Preliminary results had shown no positives, while most recipients of earlier concentrates were Chiron positive. Further study of stored haemophiliac sera was advocated."

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Dr Contreras and Dr Barbara warned that contacting and counselling affected donors would be "an enormous and costly undertaking", that using an assay test that took three hours would be logistically difficult, and that a confirmatory assay was still required.

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Dr Mitchell reported on the Abbott Symposium and presented US guidelines on the implementation of anti-HCV testing.

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Dr Peter Jones wrote to the Committee on Safety of Medicines setting out his argument for Armour materials to be withheld.

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Dr Rotblat delayed reporting Dr David Whitmore's HTLV-3 positive patient because Dr Whitmore had asked for confidentiality regarding the patient while he investigated the patient's lifestyle.

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In relation to the cost involved in changing form non-heat-treated to heat-treated material in the northern region, there was an argument as to whether people who were HIV antibody positive should continue to receive contaminated material.

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Dr Prince found that Generation I, Generation II and Factor 9 were not rendered virus free when they had been contaminated with HTLV-3 and heated in the dry state at 60°C for even as much as 72 hours, but in November 1985 Armour (US) refused permission to Dr Prince to make the information public.

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When he studied under Dr F C Webb and used his seminal textbook, Dr Foster had learned that albumin could be pasteurised at 60°C for 10 hours but the other fractions were heat labile.

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Dr Prince's report of further studies "Safety of Blood Derivatives Pasteurized in the Dry State" concluded that "pasteurization at 60C in the dry state had only a modest process efficacy for inactivation of HTLV-III/LAV".

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Serum hepatitis was inactivated by heating human albumin at 60°C for ten hours, but not for one hour.

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Dr Alfred Prince conducted his further study and found that pasteurisation at 60°C in the dry state had only a modest process efficacy for inactivation of HTLV III/LAV.

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Dr Prince found that Generation I, Generation II and Factor 9 were not rendered virus free when they had been contaminated with HTLV-3 and heated in the dry state at 60 C for even as much as 72 hours, but in November 1985 Armour (US) refused permission to Dr Prince to make the information public.

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When he studied under Dr F C Webb and used his seminal textbook, Dr Foster had learned that albumin could be pasteurised at 60C for 10 hours but the other fractions were heat labile.

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Serum hepatitis was inactivated by heating human albumin at 60C for ten hours, but not for one hour.

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