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By 1979, the issue of chronic hepatitis dominated everyone's lives.

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Dr Forbes said that by 1983, doctors were already starting to observe patients to see if there were early signs of AIDS.

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Dr Forbes acknowledged in 1983 that there was the potential for locally sourced donors to bring contaminated blood with HIV into the donor pool.

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The Belfast Haemophilia Centre was established in 1958 but until 1981 it was included in the Oxford supra-region.

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At the meeting of the Haemophilia reference centre directors held on 14 September 1981, it was noted that the annual returns for 1980 showed that the amount of Factor VIII concentrates used, especially commercial materials, had again increased.

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Dr Elizabeth Mayne became director of the Belfast Haemophilia Centre.

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Dr Mayne describing the history of haemophilia care in Northern Ireland, described patients as being "ecstatic" with the advent of cryoprecipitate which was "revolutionary".

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Hemofil was the commercial concentrate used in Belfast Haemophilia Centre

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Throughout the 1970s liver function tests performed on patients at Belfast Haemophilia Centre showed persistent abnormal liver function.

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According to Dr Mayne, there was increasing evidence that NANB hepatitis was not as benign as had been thought but could progress from chronic persistent hepatitis to cirrhosis.

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Dr Mayne enquired with Dr Craske as to the relevance to haemophilia "he reminded us that the individuals cited in the paper were known to maintain their lifestyle by being paid blood donors, as was documented in the World in Action (1975) programme."

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Dr Mayne noted manifest advantages of Factor VIII concentrates over cryoprecipitate, such as accurate calculated dosage to be given in small volume, associated with a decreased chance of clinical side effects.

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Dr Mayne stated that the possible significance of asymptomatic hepatitis became apparent by 1978, when structural abnormalities of the liver were described in patients.

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Patient discharge summary from Dr Mayne to Dr Wallace suggested the first use of Factor VIII concentrate in Belfast Haemophilia Centre.

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Dr Mayne instituted a home treatment programme using commercial concentrate, whereby all home treatment patients were treated with Kryobulin, all hospital treatment was with Hemofil while children continued to be treated with cryoprecipitate.

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David Williams of Speywood noted that Dr Mayne was not prepared to change her policy concerning human factor VIII.

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Dr Mayne wrote to David Williams, explaining that in view of likely expansion of home treatment programme and increased needs for commercial Factor VIII, further order for Koate might be placed with Speywood.

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The 1977 annual return recorded that Belfast Haemophilia Centre used no NHS Factor VIII concentrate.

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The 1976 annual return recorded for the Belfast Haemophilia Centre the use of cryoprecipitate and commercial concentrates (Hemofil and Kryobulin). Some NHS concentrates were used.

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