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During 1978 little cryoprecipitate was used and the NHS and commercial factor VIII levels broadly remained similar to the year before at the Birmingham Haemophilia Centre

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In 1979 almost no cryoprecipitate was used and the amount of commercial concentrate was well over double the amount of NHS concentrate at the Birmingham Haemophlia Centre

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Professor Frank Hill at the time believed hepatitis was a minor self limiting condition with no serious long-term consequences

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Dr Hill and Dr Stuart were concerned about the risks of hepatitis and were of the view that it would have been advantageous to reserve NHS Factor 8 for children.

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By 1975 Dr Colvin was aware that there was at least a possibility of chronic liver disease in haemophilia

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Dr Hill reported to the December 1979 meeting of the West Midlands Working Party that the Hepatitis Working Party had reported that Commercial Factor VIII carried the risk of hepatitis, and he was concerned that some children at the Childrens Hospital had become hepatitis carriers

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In 1979, Dr Kernoff held that while cryoprecipitate was cheap to produce it had serious clinical disadvantages and that the NHS's shortfall had to be addressed through buying commercial concentrate.

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In 1979, Dr Kernoff described NANBH was a serious disease with long-term consequences.

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In 1979 Dr Kernoff and Dr Colvin authorised guidelines for the screening and investigation of liver functioning and Hepatitis B tests, implementing closer monitoring of patients.

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In December 1979, the Haemophilia Working Party met and discussed the fact that up to 70% of patients with severe haemophilia had abnormal liver function tests, with a wide spectrum of histological abnormalities.

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In 1970, at the haemophilia centre at Leeds, based at St James's University Hospital Dr Layinka Swinburne was the director and in 1985, she was joined by Dr Bernard McVerry.

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By 1977 the haemophilia centre at Leeds, based at St James's University Hospital were using a substantial amount of commercial concentrates.

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The haemophilia centre at Leeds, based at St James's University Hospital showed no evidence of batch dedication or evidence of risk reduction.

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In 1978 at the haemophilia centre at Leeds, based at St James's University Hospital very little cryoprecipitate was in use.

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In 1979 at the haemophilia centre at Leeds, based at St James's University Hospital there was no cryoprecipitate was in use.

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The haemophilia centre at Leeds, based at St James's University Hospital showed that by 1977, was using a substantial volume of commercial concentrate.

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Dr Bevan described how, in 1978, there was a limited amount of risk management that took place during that period.

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Commenting on the reaction to AIDS and the risk of transmission, Dr Bevan held that during the period around 1983, that the general attitude of doctors was not to alarm the public as there was no conclusive proof.

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During March 1983, a meeting was held, by the Haemostasis Club, where clinicians met to discuss and hold presentations that were topical to the medical field.

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Dr Bevan held the opinion that he did not understand why both UKHCDO and the reference centre directors were so slow to recognise and react to the risks of AIDS being transmitted to their patients and how he felt that it was a denial of the reality.

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