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BPL was extended in a "make and mend" operation.

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The SHHD drew up plans to build PFC and made a formal agreement with the Ministry of Health to fractionate plasma from four northern English regions.

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Dr Biggs wrote to the CMO calling for the new buildings at Elstree and in Edinburgh to be accelerated in order to enable greater domestic production of concentrates.

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Dr Maycock wrote to the DHSS urging them to "have constantly in mind the need to develop our own sources in the UK transfusion services".

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The Expert Group on the Treatment of Haemophilia met for the first time.

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The Expert Group on the Treatment of Haemophilia decided the initial aim would be to provide anti-haemophilic globulin concentrate from 250,000 donations.

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An MRC report noted that to meet the requirements of Factor 8 the total material needed was likely to be 547,540-750,000 blood donations per annum.

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The DHSS wrote to regional administrators that the immediate need for AHG concentrate, the cost of commercial alternatives, and the potential threat to the voluntary donor system meant achieving self-sufficiency was "of the greatest importance".

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Dr Owen announced the Government's committment to self-sufficiency and the allocation of special finance in furtherance of this goal.

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Dr Bidwell calculated that between 970,920 and 1,213,650 donations would need to be devoted to plasma supply to produce the required amount of Factor 8.

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At a meeting of the Expert Group on the Treatment of Haemophilia, Dr Biggs advanced an estimate of a total requirement of 40 million iu of Factor 8 across the UK.

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Dr Lane said he was unwilling to enter into an agreement with PFC to have regular quantities of plasma fractionated in Edinburgh.

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The Trends Working Group reported that UK capability was less than half what was required and that considerable further investment in collecting, testing, processing and premises was needed to meet targets.

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Minister of Health Roland Moyle recognised that the commitment to self-sufficiency had "not yet" been met.

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BPL was inspected by the Medicines Inspectorate who produced a damning report calling for urgent action.

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Ministers instructed officials to begin work on planning and designing a new BPL.

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By this time, some 90% of the blood products used in Scotland were manufactured in Edinburgh, making Scotland virtually self-sufficient.

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The Treasury approved the redevelopment of BPL at a cost of £22.6 million.

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The redevelopment of BPL was scheduled for completion at a revised cost estimate of £60 million.

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A paper presented to MRC Jaundice Committee on Prevention of Homologous Serum Jaundice recommended restricting the size of pools.

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