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Dr Vaughan finally approved a submission that had been put to him proposing expenditure of £1.3 million over two years.

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Peter Wormald noted in a memo that the success of the extra expenditure would depend on persuading RHAs to increase plasma supplies.

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Long-term upgrading was considered at a meeting of the Scientific and Technical Committee.

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It was reported to the Committee that officials had been instructed by ministers to investigate the possibility of collaborating with private industry. Initial discussions had taken place.

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Worries were expressed on various aspects of collaboration with private industry, including the fear it would be difficult to prevent the contamination of UK material with imported Hepatitis viruses.

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In a DHSS press release, Dr Vaughan announced there would be no commercial management of BPL as there was a modernisation programme already underway.

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Dr Dunhill, a member of the Scientific and Technical Committee, wrote to Dr Vaughan outlining his acceptance of the situation in the short term only from consideration of the need to maintain plasma fraction supply.

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A minister asked the Policy Steering Group for the development of BPL to give consideration to the use of an existing factory which could be adapted at a relatively low cost to meet requirements.

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Approval was sought for planning to proceed on the assumption that BPL would process all the plasma for both England and Wales as the PFC did not have additional capacity without introducing three shift patterns.

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The Treasury approved the redevelopment in principle and agreed that the project should be fast-tracked.

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In a report, Dr Lane outlined that the final cost of MARP01 would be £2.8 million.

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Construction of BPL finally began in May 1983. The original completion date was to be July 1985.

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In a written answer on the NBTS and Factor 8, Kenneth Clarke, the Minister of State for Health, stated that "We decided in 1982 that this country should become self-sufficient in blood products".

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Lord Owen's reaction to Kenneth Clarke's words on self-sufficiency, in his written statement to the Inquiry, was that it was "extremely odd" and "as if the previous Labour Government programme had never existed".

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In wartime planning, two main plants were to process plasma for the UK: one south, one north.

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Dr Cumming was an enthusiastic advocate of forward planning when it came to plasma production.

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The Ministry of Health agreed with the SHHD that the PFC would fractionate plasma for the NHS using plasma collected by the Newcastle, Leeds, Manchester and Liverpool regions.

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The Blood Transfusion Public Expenditure Survey Committee issued a report regarding a statement on forecast assessments.

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It was not until 1965 that planning for a 1972 extension to the Blood Products Laboratory, which then followed, contemplated accommodating the fractionation of plasma on any scale. This was a necessary step in producing clotting factor concentrates, though the main reason for the expansion at the time was to produce more immunoglobulin to prevent rubella in pregnancy, following an outbreak.

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Pressure on the Government to act on increasing the supply of plasma was exerted by clinicians, by the medical press, by NBTS, and by the advisory bodies which had been set up.

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