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The goal of 275,000 donations for Factor 8 production had not been met a year after it had been given from 1973 to 1974.

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Dr Maycock argued for the principle of self-sufficiency and that unpaid donations must be preserved, blood transfusion services in the UK must be self-supporting and there should be agreed UK targets for the provision of preparations of human blood. The supply of plasma for fractionation needed to increase if the shortfall in meeting the anticipated demand was to be met from within the NHS.

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An article in The Lancet demonstrated the pressure put on the Government to act by clinicians, the medical press, NBTS and advisory bodies.

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Professor Blackburn wrote to Dr Waiter, which demonstrated the pressure put on the Government to act by clinicians, by the medical press, by NBTS and advisory bodies.

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A letter was written to Dr Waiter which demonstrated the pressure put on the Government to act by clinicians, the medical press, NBTS and advisory bodies.

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Dr Waiter wrote to Professor Blackburn, which demonstrated the pressure put on the Government to act by clinicians, the medical press, NBTS and advisory bodies.

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A note of a meeting with the Minister of State (Health) outlined that the Haemophilia Society was anxious that the volume target set by the Department for self-sufficiency might not be sufficient in practice.

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A note from M Draper to Thomas Dutton noted that Dr Owen had asked to have a copy of the MRC report from which the Haemophilia Society were quoting and which had also mentioned Dr Rosemary Biggs.

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RTD (75) 26 set out regional transfusion directors' estimates of the number of donations to be used for the production of fresh plasma from AHG concentrate each quarter from 1975 to mid 1977.

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A memo from Thomas Dutton noted that a recent meeting of the Expert Group on the Treatment of Haemophilia advised that NHS Factor 8 production may have provided no more than about one third of the likely requirement for Factor 8 in a few years time.

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A note on anti-haemophilic globulin concentrate outlined that the target figure to which they were currently working was no longer sufficient to meet the probable treatment needs of people with haemophilia in a few years time, having been overtaken by the unexpected rapid introduction of home therapy.

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A letter from Gerry Grimstone to Thomas Dutton outlined Dr Owen's stance that the National Blood Transfusion Service needed to be reformed.

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In a National Blood Transfusion Service Central Committee meeting, the chairman proposed a review of the clinical use of blood and blood products, including an examination of the overall use of the blood and blood fractions.

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A document by T Dutton outlined problems facing the National Blood Transfusion Service, particularly with regard to the provision of blood components.

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The minutes of a haemophilia centre directors' meeting noted that there was a hold up in the expansion of fractionation in the UK.

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The Working Group on Trends in the Demand for Blood Products held its first meeting.

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The Working Group on Trends in the Demand for Blood Products noted in its July meeting that the size of the population with haemophilia could rise significantly. They also said: "It was apparent that clinicians were coming to recognise the supply problems; eg, they were moderating their demands for Factor VIII for prophylactic treatment."

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The estimates which had been reported by the Working Group on Trends in the Demand for Blood Products in late 1977 were largely thought to be reliable estimates for future need by the Standing Medical Advisory Committee in 1978.

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The Standing Medical Advisory Committee was constituted by the National Health Service Act 1946 and Dr Waiter noted that the Committee expected an increasing requirement for Factor 8 for orthopaedic surgery and David Smart recorded the modified figures.

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Dr Lane considered in 1979 that a redeveloped BPL could be commissioned to increase production capacity to 90 million international units between 1985 and 1990, as an intermediate stage, and then to scale up production to 120 million units for the years that followed.

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