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Dr Owen expressed his belief that the NHS should have been self-sufficient to have made the "best-known treatment more readily available to people suffering from haemophilia."

Published on: 23 July, 2024

Professor Garrott Allen (Stanford University) expressed his concern to Dr Maycock (Consultant Advisor, CMO) about commercial blood products being purchased by Britain from the United States.

Published on: 23 July, 2024

Granada screened its "World in Action programme Blood Money - Part 1" documentary in the UK.

Published on: 23 July, 2024

Granada screened "World in Action programme Blood Money - Part 2" documentary in the UK.

Published on: 23 July, 2024

Reverend Tanner (Chair, Haemophilia Society) met Dr Owen and described that he "spoke very forcibly to Dr David Owen to let him know that [he was] not prepared to accept the risk of hepatitis coming from the blood products issued from the United States."

Published on: 23 July, 2024

At a Haemophilia Society meeting, it was discussed that "Dr Owen stated that in 1977 we would be fully self-sufficient in concentrates. The whole question of commercial concentrates, plasmapheresis, the regional structure of the BTS, and other matters were fully discussed."

Published on: 23 July, 2024

A DHSS meeting minutes recorded Dr Owen stressing "his personal commitment to self-sufficiency".

Published on: 23 July, 2024

Dr Owen took Dr Maycock's advice on his criticism of the regional structure of the blood transfusion service which was recorded in Department of Health minutes.

Published on: 23 July, 2024

Dr John Cash wrote to the BMJ stating, "There is no doubt that the import into the United Kingdom of factor VIII concentrates derived from external sources, however well screened for hepatitis viruses, represents an unequivocal pathway by which the level of a potentially lethal infection into the whole community is being deliberately increased."

Published on: 23 July, 2024

Dr Cooper (Assistant Secretary for US Health, Department of Health, Education and Welfare) commented: "We feel that the warning is quite direct and adequate; in fact, it is generally appreciated in the U.S. that every lot of this particular product is probably contaminated with hepatitis B virus."

Published on: 23 July, 2024

Dr Diana Walford stated that "if somebody applied to the Medicines Division or the licensing authority, as they actually were deemed, for a clinical trial certificate or a clinical trial exemption certificate that was to be considered. It fell to be considered by Medicines Division, whether it needed to go entirely to a Committee on Safety of Medicines Meeting I think might have depended on the product."

Published on: 23 July, 2024

It appeared that there was no site examination at any of the blood collection centres in the USA.

Published on: 23 July, 2024

Dr Diana Walford recalled that upon visiting a USA manufacturing facility, the inspector and herself were very unhappy due to the lack of hygiene among other things.

Published on: 23 July, 2024

At the Haemophilia Reference Centre Directors meeting it was suggested the implication was that the cheaper (Kryobulin produced in the US) product carried the higher risk of plasma viral hepatitis which worried some Directors.

Published on: 23 July, 2024

It was mentioned at the Haemophilia Reference Centre Directors meeting that the European (red) material was still available for those who felt it carried a lower risk of conveying hepatitis, although both were equally safe.

Published on: 23 July, 2024

When marketing Factor 8 Concentrates produced from plasma of US origin and the European based material one, no distinction was made between the labelling nor the accompanying information sheets in order for clinicians to pick whichever they wanted to use.

Published on: 23 July, 2024

In an internal memo, Dr Otto Schwarz managing director of Immuno AG stated that two types of Kryobulin would be sold. KRYOBULIN 1, made from European plasma and KRYOBULIN 2, made from US Licensed Source Plasma.

Published on: 23 July, 2024

A table published in June 1983 showed that Immuno Ltd's sales of Kryobulin (Red) exceeded sales of Kryobulin (Blue) by 4.5 times.

Published on: 23 July, 2024

In a memo from Mr Wrigglesworth to Mr Parker and others it was recorded that "Miles Labs state that FVIII manufactured from plasma collected since March 83' will not be available until August, and Immuno in September 83'".

Published on: 23 July, 2024

In her written witness statement to the Infected Blood Inquiry, Dr Diana Waford made reference to the Immuno's ethical obligation regarding American Kryobulin carrying a higher risk of hepatitis.

Published on: 23 July, 2024

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