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In a Blood Money interview, Dr Craske explained the risk of larger pools, acknowledging that one donor could affect a pool and that Factor 8 should only be used in emergencies and by qualified staff.

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Dr Owen acknowledged that it was likely that he would have read Craske's article, acknowledging the risks of commercial concentrates from large pools with domestic production.

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Professor Manucci pointed out that strict adherence to the "small pool concept" in Sweden had given rise to "a very low incidence" of post-transfusion hepatitis in people with Haemophilia B, and suggested that the adoption of such a concept would be "a significant step forward".

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The Council of Europe recommended that blood collection agencies and pharmaceutical companies should give treating physicians and consumers detailed information about blood and blood related products, including the nature of the donor pool from which the products were derived.

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Dr James Smith at PFL asked Dr Lane, as the director of BPL, to agree to his increasing the pool size used to 900kg-1,000kg of plasma (roughly 4,500-5,000 donations).

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Dr Lane observed that once one had exceeded the 100kg-200kg pool size, one had already exceeded any possibility of small pool protection.

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Dr Craske felt that the increased usage of small pooled concentrates would help to reduce the incidence of hepatitis in the haemophilic population.

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Dr Smith sent a memo to Dr Lane, suggesting that three tables in a report by Dr Craske, which he had presented to the working party, "offer good ammunition against the importation of U.S. plasma or its products".

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Dr Peter Foster and Ida Dickson considered that losses in Factor 8 from having to meet quality control requirements could be reduced.

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A memo from Dr Foster to John Watt and others described the specifics of a new-scale thawing tank becoming ready for use at the start of 1981.

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In a review of tables on batches and the pool size from which they were made during this period, it was found that of the 27 batches listed only 10 were larger than 300 litres, and of these the highest figure was 555 litres (being 5 such batches).

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In a review of contemporaneous sources, pool sizes ranging from a minimum of 800 donations (200kg) to 2,200 (550kg) were used, with the size dependent on whether the smaller or the larger freeze dryer was used.

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There was an increase of around 25% from the pool sizes recorded up to 1983 after it was identified that patients from Edinburgh were infected from a batch containing 4,000 donors.

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Change to dates for expert hearings

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Sir Brian Langstaff writes to Public Health England

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Timetable for public hearings 8 October - 1 November 2019 (London)

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Instruction letters for expert groups published

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Public hearings factsheet

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Inquiry files paperwork in judicial review

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Newsletter

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