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RTCs were accountable to their RHAs, with medical and scientific oversight from the regional medical officer.

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Funding for donor recruitment campaigns was often an issue prior to the establishment of the National Directorate.

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The overall plasma target required to meet the needs of England and Wales was divided between the RTCs on the basis of the size of the population of the area covered by the RTC.

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In a letter to Dr Geoffrey Tovey, Dr Rosemary Biggs discussed seeking a larger allocation of Factor 8 concentrate for the Oxford Haemophilia Centre.

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In a letter to Dr Geoffrey Tovey, Dr Rosemary Biggs raised the issue of basing the allocation of Factor 8 on patient numbers, noting that both Birmingham and Oxford treated patients far outside their regions.

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The allocation of antihaemophilic globulin concentrate for the South Western Region was discussed in a letter from Dr Tovey to Dr Biggs.

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In a letter to Dr Rosemary Biggs, Dr Geoffrey Tovey identified that the Exeter and Bristol centres were allocated a supply for Factor 8 concentrate in proportion to the number of patients treated there, even though half the patients in the region were treated at associate centres.

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In a letter to Dr Rosemary Biggs, Dr William Maycock set out the quantities of concentrate to be allocated based upon the number of patients undergoing treatment in 1974.

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In a letter to Dr Hill, Dr Jenkins stated that the North East Thames Regional Health Authority had been supplying vast quantities of plasma for concentrate production at BPL for many years. However, due to the final product being allocated in proportion to patient needs, it had in effect been subsidising regions which did not produce as much plasma.

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The distribution and allocation of NHS and commercial concentrate was discussed at a meeting of Directors of Haemophilia/Associate Haemophilia Centres and Blood Transfusion Centres and Regional Health Authorities.

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In relation to the setting of targets of plasma collection for BPL in England and Wales, the system used was one that was not conducive to achieving self-sufficiency.

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In a letter to Dr Maycock, Dr Wagstaff stated that he was keen to harvest more plasma from donations in Trent than was then being achieved, but in order to do so he needed to persuade the RHA to invest in more double packs.

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Dr Colin Entwistle provided a phone service so products could be released from Cambridge RTC to hospitals during the night.

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Oxford RTC's plasma was sent to the PFL in Oxford which sent fractionated products directly to the Oxford Haemophilia Centre.

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Due to the fact that the donor population differed between areas, some RTCs were able to collect more blood donations than they required.

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Dr Entwistle had not been aware of the shortage in adjacent areas and later reflected that this underlined the need for a rationalisation of the service.

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A pro rata system was introduced for the supply of factor concentrate to RTCs, whereby the amount of concentrate provided to each RTC reflected the amount of plasma provided to BPL by that RTC.

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In a letter to Dr Lane, Dr Entwistle stated that the reason that Oxford's RTC did not appear on the pro rata table was attributed to the fact that half of the patients referred were not part of the region.

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The targets that were set for each RTC by BPL were not based on the amount of concentrate a region needed to achieve regional self-sufficiency in factor products. They were based instead on the population of the region.

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Due to the fact that the targets were set by BPL rather than drawn up by the RTCs, some RTCs pushed back against them because they did not agree they were set at the right level.

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