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Scottish RTCs subjected themselves to formal inspections from the Medicines Inspectors to obtain manufacturing licences. Inspections started in January 1980 and all centres had been inspected by March 1982.

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The first external inspection of the RTC in Belfast was a visit by the Protein Fractionation Centre.

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South East Thames RTC kept a quarter of product received from BPL for emergencies, and the remaining product was distributed to haemophilia centres in the area in proportion to the number of people with bleeding disorders treated at the centres.

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The North London RTC used Dr Simon Ardeman, a consultant haematologist at Edgware General Hospital, to act as the arbitrator between the various hospitals which received their Factor 8 from the North London RTC, to determine their allocation of Factor 8.

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In a letter Dr Jean Harrison explained the situation with regard to charges for Factor 8. The situation prior to 1 April 1989 was that haemophilia centres were charged for any supply of Factor 8 by BPL above their free allocation.

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The North East Thames RTC (Brentwood) ceased to act as a wholesaler for BPL products.

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In his letter to Dr William Maycock, Dr Jack Darnborough rejected the idea of distributing Factor 8 on a supra-regional basis and of RTCs distributing commercial Factor 8 as well as NHS Factor 8 and cryoprecipitate.

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Dr Jack Darnborough agreed to organise the purchase and distribution of commercial Factor 8. He noted one of the reasons for his change of mind as being his knowledge that a haematologist in his region had been purchasing large quantities of commercial Factor 8, costing between £8,000 and £10,000 a year.

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Dr William Maycock convinced Dr Jack Darnborough of the advantages of distributing commercial Factor 8.

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Barry Barber, sales manager at Cutter Laboratories, informed Dr Jack Darnborough (Cambridge RTC), about a request to tender for the next Factor 8 contract.

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Dr Jack Darnborough (Director, East Anglian Blood Transfusion Centre) met with a representative from Cutter Laboratories to discuss the supply of Koate.

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The Yorkshire RTC did not purchase, store or distribute commercial Factor 8 prior to 1981, but discussions were had with the Regional Health Authority around July 1981 regarding future policy in this matter.

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The Yorkshire RTC adopted regional purchase of all blood products.

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The Yorkshire RTC began centrally purchasing Factor 8 on behalf of haemophilia units in Yorkshire based on their individual requests.

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By January 1981, the West Midlands RTC had established the practice of holding and issuing all Factor 8 products.

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Dr Bird confirmed to Stan Godfrey that the West Midlands RTC held regional stocks of commercial Factor 8 concentrates purchased by the Regional Health Authority on the basis of calculated regional requirements and said the scheme "works very well".

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Dr Ala (Birmingham RTC) met with Linda Frith (Cutter Laboratories) to discuss the purchase of Koate HT, Albumin and Gamimune N.

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Jennifer Cole OBE

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Dr Harold Gunson cancelled all orders for BPL's non-heat-treated products for January to March 1985, citing the decision in his region to use only heat-treated commercial Factor 8 concentrate.

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A proposal from Dr Harold Gunson to the Chairman of the North Western Regional Health Authority showed that the North Western Regional Health Authority directly funded the purchase of commercial Factor 8 products supplied to the region's haemophilia centres.

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