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In the early 1970s and families were advised that "Some children may be able to have an injection to provide cover for a day or so for an important examination, or to tide them over a period when bleeds are particularly troublesome."

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The 12 multi-transfused patients with haemophilia biopsied and described in that paper reported that "only" 1 showed evidence of progression to active cirrhosis, although a further 4 patients showed some evidence of mild chronic active hepatitis.

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The haemophilia centre at St Thomas' Hospital was under the directorship of Professor Ingram until 1979, when he was succeeded by Dr (later Professor) Geoffrey Savidge.

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Professor Ingram wrote that he was "pressing on with training as many severe haemophiliacs as possible to give themselves their own treatment."

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In his letter to Dr Maycock, Professor Ingram stated that the Home Treatment Study at St Thomas' Hospital had taken in as many patients as supplies of Factor 8 concentrate allowed. Consequently, he asked for an increase in supply to take in more patients.

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Professor Ingram stated "We are of course also using considerable quantities of commercial material for surgical cover...Can anything further be done to increase NHS production?"

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Geoffrey Savidge asked what the policy of the haemophilia reference centre directors was. Professor Bloom, responded and said that it was "a matter for the individual Directors to decide."

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Professor Ludlam confirmed that he did not proactively raise the question of AIDS risks with patients, but stated that he would have answered questions if they were raised (although he could not remember such inquiries from patients).

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In oral evidence Professor Christopher Ludlum stated that he remembered not proactively informing patients of the risks of AIDS in taking concentrates around 1983/1984

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In oral evidence Professor Christopher Ludlum confirmed that he had become aware of AIDS in haemophilia patients in around August to October 1982

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In oral evidence Professor Christopher Ludlum emphasised that there was a lot of uncertainty at that time around AIDS and the cause of AIDS

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Professor Christopher Ludlum stated that at the time he had felt that the case of the San Francisco baby had been circumstantial evidence

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Professor Christopher Ludlum had stated that Dr Craske had been a virologist and therefore would see things from that perspective so he was not surprised that in a meeting Dr Craske had not noted any links for AIDS in haemophilia patients

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Professor Christopher Ludlum had stated that he had thought PFC concentrates had been reasonably safe and they had felt it reasonable to continue using cryoprecipitate

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Professor Christopher Ludlum had not been able to recall his views from 1984, however his practice in Edinburgh had stopped using cryoprecipitate for children

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Professor Christopher Ludlum stated in oral evidence that he had sent samples to Dr Tedder without the patients or their parents knowledge or consent

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Professor Ludlam wrote to patients inviting hundreds to a meeting to discuss anxieties raised. This was sent to those personally affected but due to a lack of explanation they did not realise. Only a few tens of people turned up to the meeting.

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Professor Christopher Ludlum recalled that his reasoning for sending the samples were to see if those who had received commercial products were positive and those with Scottish Factor VIII had been negative

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As a junior registrar at Edinburgh, Dr Robert Carr did not have discussions with patients about AIDs as the causative agent had not been identified at the time.

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A witness to the Inquiry with von Willebrand disorder was treated with Factor 8 for the first time in 1981 and 1982. She thought it unlikely that she was told of any risks as she would have questioned whether there were alternative treatments available.

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