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The haemophilia centre at St Thomas' Hospital was under the directorship of Professor Ingram until 1979, when he was succeeded by Professor Geoffrey Savidge.

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In late 1972, Professor Bloom described the local supply of cryoprecipitate as "quite good", however that he would prefer to use freeze-dried concentrate if available.

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In 1976, Professor Bloom explained that while Cardiff used cryoprecipitate for ordinary bleeds, they needed freeze-dried material for the treatment of inhibitors and for home treatment.

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When considering Factor 8 supply, Professor Bloom had stopped using Armor product due to the hepatitis problem and he also no longer bought Immuno because the price was too high.

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Annual return from 1976 displaying the results of the treatment of Haemophilia A in Cardiff through the use of substantial quantities of cryoprecipitate, very modest amount of NHS concentrate, significant amounts of Kryobulin and Hemofil, as well as the use of small amounts of Factorate, Profilate and Koate.

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Annual return from 1977 showing that cryoprecipitate was used twice as much as commercial concentrate (primarily Hemofil) than NHS concentrate was used in Cardiff.

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Annual return regarding Cardiff Haemophilia Centre from 1978 showing that cryoprecipitate was used twice as much as commercial concentrate. Factorate was the largest in volume as well as substantial quantities of Koate and Hemofil also used.

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Annual return from 1979 showing that significant cryoprecipitate were still in use in the Cardiff Haemophilia Centre, but that over a million units of commercial concentrate was in use, compared with 328,538 units of NHS concentrate.

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In relation to the risks of hepatitis, Professor Bloom described to another clinician that a small percentage of these freeze dried preparations contained unavoidably the virus of serum hepatitis and therefore were potentially dangerous to the patient and their relatives.

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During the time that Professor Ludlam was working in Cardiff, he recalled Professor Bloom speaking about the Bournemouth hepatitis outbreak of 1974, making the Cardiff director cautious about US concentrates.

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The geographical area of the Royal Edinburgh Infirmary covered patients in the south of Fife, Kirkcaldy, Dunfermline and most of the Borders.

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During the 1970s, at the Edinburgh Royal Infirmary, the preferred choice of treatment of Dr Howard Davies was cryoprecipitate, with no commercial concentrates being used.

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When Dr Ludlam became director in 1980, his approach to treatment was the following: First, he not only made primary treatment from Haemophilia A became Factor 8 concentrate, but also increased the use of factor concentrates as a whole. Second, he increased the number of patients using home treatment.

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The effect of Professor Ludlam's introduction to factor concentrates was that the local blood transfusion service redirected donor blood plasma from cryoprecipitate production to concentrate manufacture.

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Towards the end of 1982, concerns arose as to the increased demand and limited supply of commercial treatment following the increase in home treatment. It was therefore necessary for more commercial product to be imported and Dr Ludlam agreed to keep up with the demand.

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Professor Ludlam described in his oral evidence how in many cases children with Haemophilia A would begin with cryoprecipitate before moving to home treatment.

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Professor Ludlam described how batch dedication was introduced towards the end of 1984 and it unclear why this was not produced earlier.

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Professor Ludlam, under counsels questions, amended his earlier submission that in the late 1980s, NANB Hepatitis was believed to be a mild non-progressive condition following the first liver biopsy undertaken in 1985. He corrected this view to say that he was aware of the liver biopsy undertaken in Sheffield in 1978, and thus there was a likelihood of prior knowledge of the condition of NANB Hepatitis earlier than the late 1980s.

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Professor Ludlam stated that during the 1980s that there was a wide view at the time regarding the seriousness of NANB Hepatitis. The lack of evidence about its progressiveness that resulted in the belief that it's possible it might not be progressive however it became clear that there was a wide range of ways in which it rates at which it did progress between different people.

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Dr Saad Al-Ismail who worked with Professor Bloom in Swansea recalled Professor Bloom stating that NANBH was probably not going to be an issue for the vast majority of patients.

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