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In 1984, NHS Factor Concentrate was the most used blood product provided by Sheffield Children's Hospital. Cryoprecipitate was also used.

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In 1985 cryoprecipitate and NHS concentrates were the main treatments provided at the Sheffield Children's Hospital. Autoplex was used for those with inhibitors, and a small amount of Hyate C (porcine Factor 8) was used.

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A paper was published which recorded the outcome of liver biopsies in five boys with severe haemophilia who had persistently abnormal liver function tests, Abnormal histology was present in all. It was concluded that cryoprecipitate should be used in preference to large pool Factor 8 concentrates in children with haemophilia.

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One child was infected with HIV at the Sheffield Children's' Hospital.

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Nicholas Calder was swapped from cryoprecipitate to factor VIII concentrate. His mother did not consent to the change and was never informed of the viral risk in the blood product. Nicholas was mostly treated with NHS concentrate but received commercial products several times.

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Rosemary Calder sought advice from Dr Cecil Reid about AIDS and was told to carry on with her son's home treatment as normal because the risk of contracting an infection was minimal.

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Ms Calder did not consent to a HIV test which confirmed her son was HIV positive at 11 years old. They were informed by a letter in the post.

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A mother whose son's treatment was changed from cryoprecipitate to Factor 8 concentrate was given no warnings about the products at Charing Cross Hospital

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Alan and Christine Fowle were called to the hopsital and told in person that their son had been infected with HIV when he was nine years old but were given no other information or advice. They were told it was generally a disease in the homosexual community exclusively.

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Mr and Mrs Fowle were told their son might not live another 12 years. They told Christopher of his diagnosis when he was 15. He died aged 21.

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A young man with mild Haemophilia B underwent a non-vital operation in 1984 to remove a birthmark, following which he received treatment with Factor 9 concentrate which infected him with Hepatitis C, when it was known that factor replacement therapy was potentially both HIV and Hepatitis C infectious. At no stage was any cautionary information given. He only learned that he had Hepatitis C in 1999.

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The parents of a one-year old previously untreated boy with Haemophilia A, was treated with concentrate in July 1983 at the paediatric ward at the University Hospital of Wales, were not told by any of the treating clinicians that there was a risk of NANBH, even though Professor Bloom informed the GP a few days later that "all these materials carry the risk of hepatitis, particularly non-A non-B, but this is something haemophiliacs have to accept".

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In a letter Professor Bloom outlined all factor concentrate carried the risk of hepatitis, particularly non-A, non-B, and this was something that haemophiliacs would have to accept.

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A man with mild haemophilia, given concentrate as part of training sessions in 1982 at the Royal Liverpool Hospital as a child, explained that his family was "told Factor VIII was safer, less bulky, easier to store and easier to use than Cryoprecipitate." He discovered he was Hepatitis C positive only in 1994 when attending a standard review at the Haemophilia Centre, not having been told that he was being tested.

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A boy whose care was reviewed at Oxford was switched from cryoprecipitate to concentrates in 1976. Dr Rizza wrote to his referring haemophilia clinician advising to treat him with the N.H.S. concentrates and as a last resort it may be justified to put him onto one of the commercial Factor VIII concentrates. The reason for that recommendation was not specified and his parents were never told of any risk of infection associated with the use of factor concentrates.

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From 1980 an individual was largely treated with commercial concentrates, with there never being any discussion with his parents about that or the reasons for it. He attended a routine clinic appointment in Nottingham in April 1985 following which his blood was tested for HIV without his knowledge.

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The mother of a boy infected with HIV following treatment with Armour's heat-treated Factorate was told of her son's diagnosis by telephone

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An individual who was unaware that his blood was tested for HIV received a letter from Dr Theodore Blecher referring to the results on recent blood samples and requesting for a meeting to discuss the results

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A patient recalled in their witness statement to the inquiry that he was told that Factor VIII was safer, less bulky, easier to store and easier to use than Cryoprecipitate. His parents were assured that if he were to contract hepatitis it would be no more severe than a bad cold.

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Matthew Johnson stated in oral evidence that his parents were assured and were told that Factor VIII concentrates was ground-breaking, it was clean and it was as good as good could be.

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