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Guidelines on the administration of blood and blood components noted that as of 1999 there were "no recognized guidelines on which to base local procedures for the ordering and administration of blood and the management of transfused patients."

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Many of the guidelines published during the 1980s focused on issues of blood bank documentation and record-keeping, including by the British Committee for Standards in Haematology, part of the British Society for Haematology.

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At a meeting of the Northern Ireland Advisory Committee on Blood Safety a report from the Autologous Blood Transfusion Working Group was circulated . In this report various transfusion methods were assessed for feasibility, including autologous pre-donation, inter-operative cell salvage, and acute normovolaemic haemodilution

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A second circular on Better Blood Transfusion was produced by the Department of Health Northern Ireland.

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The Working Party on Autologous Transfusion working party produced guidelines for pre-deposit autologous transfusion.

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The British Committee for Standards in Haematology issued guidelines for the implementation of MBOS.

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The British Committee for Standards in Haematology guidance on blood transfusion of infants was updated.

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The British Committee for Standards in Haematology published guidance which recognised that babies in special care units were "amongst the most intensively transfused of all hospital patients."

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The Department of Health and Social Security Circular on "Blood Transfusion: Record-keeping and stock control arrangements" was produced.

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A management executive letter was circulated setting out the same action points required of NHS Trusts to improve transfusion practice and Wales also issued the same guidance.

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In January 2001 Better Use of Blood in Northern Ireland guidelines were issued.

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The DHSS took the view that the use of untested blood was "highly undesirable"; unnecessary because "testing can be done in a matter of minutes" and that there could be "no excuse for not labelling blood...properly and for not keeping adequate records".

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Dr Contreras discussed her concern and disapproval of with Professor Yacoub using fresh warm blood "on numerous occasions" but understood that he continued "bleeding members of staff, visiting doctors and members of the Armed Forces for his numerous 'emergencies'."

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Dr Contreras raised a problem with Dr Burman at the National Heart and Chest Hospital where Professor Yacoub practised, and wrote to Professor Yacoub to complain of his practices. She also sought advice on her legal position if she complied with Professor Yacoub's requests, on which the Medical Defence Union supported her approach.

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Major General Hugh Jeffrey's Modern Transfusion Practice Health Bulletin emphasised the need to give a patient only components of blood which he lacked thus considerably eliminating the extent of reaction, infection and sensitisation.

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Memo from Dr O'Shaughnessy noted there had been a 15% reduction of red cell use in surgery following the first two Better Blood Transfusion circulars.

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Professor Murphy led a survey of NHS Trusts in England to determine the progress made in blood transfusion since the first Better Blood Transfusion conference.

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Guidance was published in Northern Ireland recommending that acute hospitals and health boards should establish committees in order to monitor and audit blood use

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Letter from Kevin Woods to Colleague advising 8 out of 169 reported serious hazards involved a viral or bacterial infection

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Paid for service, pre-operative autologous donation was used widely from the mid 1980s when there was increasing concern about the safety of donated blood

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