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The "Daily Mail" published a front page article with the headline "AIDS Virus kills man in Britain".

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The "Daily Express" published an article titled "Twin bid to curb killer AIDS peril".

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"The Times" published an article titled "Treated blood cuts Aids risk to haemophiliacs".

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Douglas Starr, in his book "An Epic History of Medicine and Commerce" commented: "Once AIDS became an acknowledged reality, the drug firms quickly developed screening tests and virus-killing technologies...If they had heeded the warnings of Factor VIII...they would have abandoned the high-risk collection centres sooner and worked more intensively on virus-killing technology."

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Professor Titmuss published his book "The Gift Relationship".

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The use of genetically engineered blood clotting agents was announced in October 1988 at the Royal Free Hospital.

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At a Haemophilia Society Executive Committee meeting it was reported that "the introduction of heat-treated materials has been 'patchy' and that at least one Supra-Region had not yet introduced heat-treated materials."

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Dr Denis Donohue of the FDA asked the pharmaceutical companies to stop using blood collected from donors likely to have high levels of antibodies to hepatitis.

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By this time, self-sufficiency had largely been achieved.

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Experiments were conducted by Dr Shohachi Wada on behalf of Cutter to see if the hepatitis virus with which Factor 9 was spiked could be inactivated whilst the Fator 9 was kept active.

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Leveton and others published "HIV and the Blood Supply: An Analysis of Crisis Decisionmaking".

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Dr Edward Shanbrom, who worked as a vice-president of medical and scientific affairs at Hyland, developed the first commercially marketed freeze-dried Factor 8 concentrate. However his suggestions only attracted minimal support in the 1970s and very early 1980s.

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In Parliament, Baroness Jean Trumpington made clear that NHS products derived from screened plasma would become available for distribution during August 1986 throughout the UK.

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A surveillance of previously untreated patients for possible virus transmission by BPL Factor 8 and Factor 9 Concentrates, 8Y and 9A, was carried out in September 1986.

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BPL's work on heat treatment - regarding Factor 9 - only really started in 1982.

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The concern that heated Factor 9 concentrates might cause thrombosis was one that had to be resolved before its product could be issued. As a result experiments in dogs were conducted prior to clinical trial in humans.

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Hyland had a research project aimed at eliminating NANBH in factor concentrates that was being hindered by a lack of manpower and adequate funding.

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In February 1979 Hyland learnt of Behringwerke beginning clinical trials in 1978 in Germany on "Factor VIII Behringwerke" via a report to their head office, later confirmed by another Hyland employee.

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Hyland had heard that the clinical trials of the Behringwerke product were almost complete and had promising results.

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Hyland listed hepatitis risk removal from Hemofil as a project proposal. It noted that the removal of the risk of hepatitis transmission by Hemofil was needed in order to allow sales of the project excess inventories at the highest possible selling price.

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