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At its first meeting, the UK Working Party on Transfusion-Associated Hepatitis agreed that Dr Gunson would ask the MRC if samples from the 1974 UK prospective study on transfusion associated hepatitis could be made available.

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Dr Gunson asked the MRC if samples from the 1974 UK prospective study on transfusion associated hepatitis could be made available.

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The MRC sought further information on Dr Gunson's request on samples from the 1974 UK prospective study on transfusion associated hepatitis, including where Dr Gunson believed the samples might be held.

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Dr Brian McClelland outlined two options for the 1974 UK prospective hepatitis study and suggested that a multi-centre study of this type would cost between £250,000 and £500,000.

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Dr Brian McClelland contacted Dr James regarding an abstract of prospective study on possible non-A non-B post-transfusion and the availability of samples from their study.

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Dr James expressed a willingness to collaborate with the Working Party on providing samples from their earlier study while noting he and his colleagues wished to avoid defrosting and refreezing their stored sera on too many occasions.

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Dr Gunson stated in a letter to Dr Keith Gibson that unless they were able to obtain data relating to the situation within the UK, they may be placed in the position of taking up a test, for medico-legal considerations if nothing else, developed abroad where the incidence or characteristics of the illness differs from that in the UK and such a decision could cost the NHS millions each year.

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Dr Gibson of the MRC informed Dr Gunson that many of the samples from the previous MRC study had been lost as a result of power failures, an audit of what was left would be carried.

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Professor Zuckerman informed Dr Gibson that a duplicate set of samples had been disposed of.

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Dr Gunson told the Working Party on Transfusion Associated Hepatitis that many of the samples from his previous MRC study had been lost due to a power failure. The Working Party acknowledged that this ruled out the chance of updating the testing of samples from that study with modern diagnostic assays.

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The Working Party on Transfusion Associated Hepatitis noted that no source of funding had been found to date for Dr Brian McClelland's proposed study.

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The Working Party on Transfusion Associated Hepatitis discussed the possibility of seeking funding from the MRC for a joint study involving Edinburgh and the North London Blood Transfusion Centre. Dr John Barbara planned to speak to the Director and submit a draft proposal.

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The Working Party on Transfusion Associated Hepatitis discussed potential requests to Dr James of the Freeman Hospital for access to samples from his prospective study of 248 patients who had undergone cardiac surgery.

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Dr James and his colleagues published the results of a study on post-transfusion hepatitis after cardiac surgery which suggested that NANBH after blood transfusion "from a largely British blood donor group probably leads to clinically significant chronic liver disease very rarely indeed."

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In oral evidence to the Inquiry, Dr Brian McClelland stated that he never saw a follow-up proposal from Dr Barbara in relation to a joint study involving Edinburgh and the North London Blood Transfusion Centre.

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In oral evidence to the Inquiry, Dr Brian McClelland described the transfusion service as "losing sight of" NANBH for several years from 1983 due to preoccupation with HIV/AIDS.

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In oral evidence to the Inquiry, Dr Brian McClelland explained that ALT levels was only a small element of his proposal for a comprehensive study.

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In oral evidence to the Inquiry, Dr Brian McClelland accepted that nothing had really moved on since the beginning of the 1980s in relation to NANBH surrogate screening study.

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In oral evidence to the Inquiry, Dr Brian McClelland explained that the letter "Testing blood donors for Non-A, Non-B Hepatitis: irrational, perhaps, but inescapable" published in the Lancet was written partly out of extreme frustration at the fact that the appropriate epidemiological studies with donors and recipients had repeatedly not been done.

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In oral evidence to the Inquiry, Dr Brian McClelland agreed with the description of "decision paralysis" in relation to the situation with introduction of surrogate screening and undertaking of the respective study from the early 1980s through to the end of 1988.

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