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Melinee Kazarian

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Anne-Maree Farrell

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Julian Savulescu

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David Armstrong

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Sir David Spiegelhalter

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Jane Anderson

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Professor Bloom assessed the size of the risk of AIDS by making reference to the number of AIDS cases developed in the UK and Europe amongst people with haemophilia.

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Christopher Bishop described Professor Bloom as an influential figure and said he was later described by the pharmaceutical company's UK marketing manager as an "opinion former".

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A memorandum from Dr Peter Foster to John Watt stated the assertion that the risk of contracting AIDS was one in one million.

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The DHSS produced a public information leaflet for blood donors which stated that "Should just one of the donors be suffering from AIDS, then the Factor VIII could transmit the disease."

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Minutes of a UKHCDO meeting recorded that Dr Malcolm Chisholm wondered if directors could revert to cryoprecipitate, given the "worry of patients" to which Professor Bloom responded that "he felt there was no need for patients to stop using the commercial concentrates because at present there was no proof that commercial concentrates were the cause of AIDS".

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At a Reference Centre Directors' meeting, Professor Bloom stated that it was "difficult to avoid the argument that non-HT [non-heat treated] constitutes a risk."

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Professor Bloom argued publicly and very strongly for steps to be taken to reduce or eliminate the risk of HIV transmission, without arguing that there was yet no conclusive proof that heat treatment would necessarily be safe.

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The Haemophilia Society informed the DHSS that they wanted to discuss - among other subjects - the "no ban on the importation of American concentrates."

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Dr Walford referred to "the cries from some quarters to ban the import of Factor VIII". It was not universally accepted at the time.

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The functions of the Secretaries of State for Health of the UK, as Licensing Authority, under the Medicines Act 1968, were discharged by the Medicines Division of the DHSS.

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The Sub-Committee on Biological Products ("CSM(B)") worked on its own.

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The CSM(B) members would know the views of the Medicines Division staff, for their reports did not simply summarise any danger but expressed a view on it.

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Professor Sir Michael Rawlins did not know why the CSM had not pressed for greater transparency at an earlier stage.

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Professor Sir Michael Rawlins believed side effects of medicine "was a judgment of balancing safety and efficacy."

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