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At a meeting of the Expert Group on the Treatment of Haemophilia, Dr Biggs advanced an estimate of a total requirement of 40 million iu of Factor 8 across the UK.

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Dr Lane said he was unwilling to enter into an agreement with PFC to have regular quantities of plasma fractionated in Edinburgh.

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The Trends Working Group reported that UK capability was less than half what was required and that considerable further investment in collecting, testing, processing and premises was needed to meet targets.

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Minister of Health Roland Moyle recognised that the commitment to self-sufficiency had "not yet" been met.

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BPL was inspected by the Medicines Inspectorate who produced a damning report calling for urgent action.

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Ministers instructed officials to begin work on planning and designing a new BPL.

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By this time, some 90% of the blood products used in Scotland were manufactured in Edinburgh, making Scotland virtually self-sufficient.

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The Treasury approved the redevelopment of BPL at a cost of £22.6 million.

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The redevelopment of BPL was scheduled for completion at a revised cost estimate of £60 million.

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A paper presented to MRC Jaundice Committee on Prevention of Homologous Serum Jaundice recommended restricting the size of pools.

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Representatives of the MRC Jaundice Committee and the Ministry of Health met and decided to use small pools.

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In the leading textbook on blood transfusion in clinical medicine Professor Patrick Mollison wrote the use of large pool plasma had been abandoned.

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WHO Expert Committee on Hepatitis made recommendations of methods that should be adopted to reduce the risk of spreading serum hepatitis, including control of pool size.

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A Ministry of Health, MRC and Department of Health for Scotland study showed restricting the size of plasma pools greatly reduces the incidence of jaundice.

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BPL had plans to move to a pool size of 250 litres (thus some 1,250 donations).

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Dr John Craske reported on the outbreak of hepatitis in Bournemouth, and referred to the risk of using large pool concentrates which he considered was associated with the outbreak.

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The pool size used to make concentrates at BPL increased from 830 to 2,000 donations per pool.

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The maximum pool size at BPL was 1,500 donations.

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The Royal Sanitary Commission described how important "public" health was, stating: "The importance of the subject cannot be too highly estimated. The constant relation between the health and vigour of the people and the welfare and commercial prosperity of the State requires no argument. Franklin's aphorism, 'public health is public wealth' is undeniable".

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The Committee of Inquiry into the Future Development of the Public Health Function was established in response to two outbreaks of communicable disease (one of salmonella food poisoning in a Wakefield hospital in August 1984, and one of Legionnaires' disease at Stafford in April 1985).

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