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Responding to the requirement to seek Home Affairs Committee clearance before policy approval, Andrew Lansley stated in his written statement that "The Deputy PM will have responded giving HA Committee clearance."

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Recommendations of financial relief in relation to the contaminated blood review were presented to Anne Milton which set out a variety of options for the Government to consider.

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A report was produced entitled "Review of the support available to individuals infected with Hepatitis C and/or HIV by NHS-supplied blood transfusions or blood products and their dependants."

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Anne Milton set out, in a undated letter to David Cameron, a summary of the report by the Department of Health on the financial support available for individuals infected with Hepatitis C/HIV.

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In his written statement, Sir John Major described the Government as a "great tanker and takes time to turn around" in relation to payments to non-haemophilia patients who were infected with HIV through blood transfusions.

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In Roderick Murray's "Viral Hepatitis Bulletin of the New York Academy of Medicine", he showed that an exceptionally small amount of blood containing a virus could be infective.

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In Barker et al's "Transmission of Serum Hepatitis", featured in the Journal of the American Medical Association, the high infectivity of hepatitis was echoed.

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In Dr Rosemary Bigg's book "The Treatment of Haemophilia A and B and von Willebrand's Disease", she cited Roderick Murray's 1955 work, which identified that even an exceptionally small amount of blood containing a virus could be infective.

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A study carried out by Gocke said that, in total, 74% of the recipients of blood con_taining the Australia antigen exhibited either hepatitis or an immune response.

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At a meeting of blood transfusion officers they discussed the proposal that the pool size used at the Cambridge drying plant for plasma should be reduced to a size of no more than 10 donors.

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The British Medical Journal article had a footnote which said that "We understand that only small pools are now used by the Ministry of Health for the preparation of blood products."

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In a letter to a Dr Lehane, Dr Maycock stated that all large pool plasma should be replaced with small pool plasma and that the large pool plasma could be diverted to Liverpool so that the small pools could be examined for infectivity.

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A study of British Army records concluded that plasma was more icterogenic than whole blood and one reason for this was likely because one bottle of plasma came from a pool to which many donors contributed.

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In a letter to Dr Maycock, Dr Drummond stated that he did not think it was justifiable to continue to issue large pool plasma which had a 10% incidence of homologous serum jaundice as opposed to 1% for small pools, and that were a case of this to go to court it would not be justifiable since it was practicable to make small pools.

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A study by Biggs in the British Journal of Haematology described the process of preparing Factor 9 concentrate using 45-50 litres of plasma.

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Pools used to prepare antihemophilic factor were 14-22 litres in size. This amounted to the use of pools made from a maximum of 90-110 donations. There was said to be no "contra-indications to the prolonged or repeated use of the product."

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Dr Peter Wolf commented "The risk of contamination of blood with the virus of infective hepatitis limits a single fractionation batch to a donor pool of 50" but "Human A.H.F. concentrate, produced in this way at multiple centres throughout the country, could provide sufficient to treat all the known classical haemophiliacs in Great Britain."

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Dr Maycock and Leon Vallet proposed to "retain the present pool size (30L) because of the risk of transmitting serum hepatitis."

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A working party on human antihaemophilic globulin decided "it was considered inadvisable, when planning increased production, to increase the plasma pool volume much above this size (30-40 litres in volume), unless further observations indicated that the risk was smaller than the present series of cases suggested."

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Dr Maycock wrote that in the UK antihaemophilic globulin ("AHG") was made from donor pools of 60-100 donors, and described a "paucity of reports of hepatitis" associated with this.

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