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In a letter from M Draper to Thomas McLean, it was noted that although the programme to secure plasma for the production of Factor 8 blood products was underway, an increase in plasma supply was not anticipated for some months and the situation was to be kept under review.

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In a memo from Dr Archibald McIntyre to Dr Bell, concern was noted that the growth of plasmapheresis might deter donors.

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The SHHD asked the DHSS when the Protein Fractionation Centre would be provided with English plasma for fractionation.

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During the closing submissions made on behalf of the DHHS and NHSBT to the Inquiry, emphasis was placed on the constrained financial position of the UK during the 1970s.

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During the closing submissions made on behalf of the DHSC to the Inquiry, some reasons for the delay in achieving in self-sufficiency included the withdrawal of the Lister Institute from the running of BPL, the constraints of the site BPL occupied, and the time it took to purchase land from the Lister Institute to enable expansion.

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During the closing submissions made on behalf of the NHSBT to the Inquiry, emphasis was placed on the constrained financial position of the UK during the 1970s.

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In a memo from Gwen Watson to Strachan Heppell, it was noted that the BPL project had been "badly handled".

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In a memo from Michael O'Connor to Strachan Heppell, it was noted that the BPL project was a "shambles".

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Although Northern Ireland was able to make cryoprecipitate from local blood donors, it was too small to produce factor concentrate itself.

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The quantity of NHS factor concentrate used in Northern Ireland increased dramatically once Northern Irish plasma began being sent to the BPL, as Factor 8 concentrate manufactured at Liberton was sent in return.

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Prescribing choices in England and Wales (being the choices that would be reflected in demand) were being formed when imported commercial Factor 8 filled the gap left by BPL's failure to supply, and this continued into the early 1980's.

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The increasing use of plasmapheresis for collection was pursued as it was a safer base material to manufacture concentrates due to the larger donation that was able to be extracted (the amount of plasma from one donation of whole blood was 40% of that from a donor of plasma by plasmapheresis).

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In Scotland, the national blood service defined self-sufficiency in blood products as the production of enough factor concentrate from a country's own resources to meet clinical need without the need for importation.

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At a meeting of the Blood Products Laboratory, it became clear that PFC's construction would cost more than the sum approved, and that despite a planned 1,500-litre capacity, it would initially only operate at 1,000 litres per week to reduce cost.

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It was estimated that 74 million international units of Factor 8 could be produced in the UK once the requirements for albumin were met.

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During this period, government funding was exceptionally constrained, inadequate and difficult to obtain for the redevelopment of BPL and the production of additional plasma for national self-sufficiency.

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Dr Angela Robinson was an enthusiast for plasmapheresis, and set up a pilot unit in Yorkshire.

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Dr Cumming was the regional transfusion director for Edinburgh and South East Scotland, a professional advocate for plasmapheresis, and was also one of the first three Scottish blood donors to reach 200 donations.

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In The Voluntary Blood Donor, Dr Cumming noted that the inadequacies that existed in modern developed countries were entirely the fault of the organisation of the service, and that forward planning was important for a successful voluntary blood donor system.

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In a Department of Health report, it was concluded that very few countries were capable of completely satisfying their blood needs (ie becoming self-sufficient) without acquiring a proportion of blood from paid donors.

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