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Dr Ian Fraser at South Wales RTC stated that "there is no way that we can expand our plasma output with a diminishing establishment and a reduced budget" and that they did not have the staff to carry out the work that the introduction of SAG-M would incur.

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The Northern RTC experienced lower donor numbers following the loss of workplace donation sessions after the closure of shipyards and steelworks in the North East.

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Professor Cash criticised the NBTS system, claiming that severe shortages of blood could arise in one part of the country, while other regions were collecting more than they required.

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Professor Contreras accused Professor Cash of "gross exaggeration", stating that in her experience neighbouring areas promptly respond to calls for help with blood supply shortages and that "no patient has ever been put at risk because of a lack of blood supplies".

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Dr Williamson reported concern about the very high level of stock holding of blood at the East Anglia RTC, and felt that steps could be taken to reduce the intake.

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After Dr Gunson's appointment as national transfusion director, he set up a program to coordinate the stocks of blood and its components in England and Wales on a daily basis, with each RTC faxing daily stock lists to Dr Moore.

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Supplies of red blood cells for the South Thames RTCs were sourced from as far away as Manchester and Scotland.

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Supplies of red blood cells for the South West RTC were sourced from as far as away Glasgow.

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The Trent RTC acted as a reference laboratory for hospital blood banks in the area and provided regional services for antenatal blood groups, serology and for histocompatibility.

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RTCs were accountable to their RHAs, with medical and scientific oversight from the regional medical officer.

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Funding for donor recruitment campaigns was often an issue prior to the establishment of the National Directorate.

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The overall plasma target required to meet the needs of England and Wales was divided between the RTCs on the basis of the size of the population of the area covered by the RTC.

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In a letter to Dr Geoffrey Tovey, Dr Rosemary Biggs discussed seeking a larger allocation of Factor 8 concentrate for the Oxford Haemophilia Centre.

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In a letter to Dr Geoffrey Tovey, Dr Rosemary Biggs raised the issue of basing the allocation of Factor 8 on patient numbers, noting that both Birmingham and Oxford treated patients far outside their regions.

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The allocation of antihaemophilic globulin concentrate for the South Western Region was discussed in a letter from Dr Tovey to Dr Biggs.

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In a letter to Dr Rosemary Biggs, Dr Geoffrey Tovey identified that the Exeter and Bristol centres were allocated a supply for Factor 8 concentrate in proportion to the number of patients treated there, even though half the patients in the region were treated at associate centres.

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In a letter to Dr Rosemary Biggs, Dr William Maycock set out the quantities of concentrate to be allocated based upon the number of patients undergoing treatment in 1974.

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In a letter to Dr Hill, Dr Jenkins stated that the North East Thames Regional Health Authority had been supplying vast quantities of plasma for concentrate production at BPL for many years. However, due to the final product being allocated in proportion to patient needs, it had in effect been subsidising regions which did not produce as much plasma.

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The distribution and allocation of NHS and commercial concentrate was discussed at a meeting of Directors of Haemophilia/Associate Haemophilia Centres and Blood Transfusion Centres and Regional Health Authorities.

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In relation to the setting of targets of plasma collection for BPL in England and Wales, the system used was one that was not conducive to achieving self-sufficiency.

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