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Dr Gunson stated that plasmapheresis should be addressed further and that centres with a 3-4 million population were ideally suited to that method of plasma collection.

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In Dr Gunson's notes on a visit to the Yorkshire RTC, he commented on the automated machines operating at the Yorkshire RTC spread across three sites, staffing and agreed targets.

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In a visitors note to the North East Thames RTC to discuss plasma supply, it was stated that Dr Harrison did not consider plasmapheresis to be an efficient way to collect plasma.

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In her written statement, Dr Harrison stated that recovered plasma was preferred to manual or machine plasmapheresis as it was much cheaper. It did not involve the cost of plasmapheresis equipment or static centres.

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In the transcript of Dr Lloyd's oral evidence he stated that the Newcastle RTC had a small plasmapheresis unit, but mostly plasma was recovered from whole blood donations.

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In his written statement, Dr Lloyd stated that the Newcastle RTC increased its plasma production for fractionation; the 1992/1993 plasma production figures, based on tonnes of plasma per million population, put the Newcastle Centre third behind the North London and Yorkshire centres.

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In the BPL and PFL Annual Report it was reported that plasmapheresis continued to grow as a source of plasma. In 1986/87 it gave rise to just over 10% of the plasma sent to BPL.

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In a memo from Dr Smith to Dr Lane, the possibility of small pool freeze-dried cryoprecipitate was discussed.

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The Chronological Presentation on the Domestic Supply of Blood Products in England and Wales held that expenditure for 1976/77 was set at £433,000 before cost adjustments, including revenue allocations.

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In a memo, it was noted that the Northern and West Midlands regions had not committed to providing plasma. The Northern region was offered increased capital, and the West Midlands region was offered an increased revenue allocation.

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In the minutes of the 163rd regional transfusion directors' meeting, the chairman was recorded as saying that 90% of the plasma production for Factor 8 concentrate had already been achieved.

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In response to a parliamentary question, Roland Moyle stated that the production of Factor 8 estimated in 1975 was exceeded by July 1977 and production had risen substantially since then.

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In a note to Dr Maycock, Dr Ellis expressed that expansion to producing 25 million international units of Factor 8 per year would cause a serious overcrowding of facilities, unless some additional building work was done.

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In her evidence Dr Walford agreed that it was or should have been known to all those involved with BPL in the second half of the 1970s that the demand for blood products was rising, that it was or should have been obvious that BPL was outdated and too small, and that significant investment was required in order to be able to meet the rising demand, and that the Government had determined that BPL should meet standards equivalent to those expected of commercial plants.

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Dr Waiter wrote in a memo that in order to meet the anticipated demand for the principal plasma fractions, a new plant would have to be acquired. Plans for the future development of BPL had by this time been drawn up.

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Concerned with costs, the DHSS advised that there was no money available for either the stop-gap proposals or an upgrade of BPL.

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In a letter, J Brown advised Mr Williams that the Medicines Inspectorate report had highlighted the severe shortcomings of the standards at BPL and that had the laboratory not had Crown immunity activities would have been suspended immediately.

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John Harley wrote a memo that noted he had tried to dissuade the Scientific and Technical Committee from initiating planning as no decision had yet been taken to build a new fractionation plant at BPL and there was no budget for even a development plan.

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Dr Vaughan, then the Minister of State for Health, agreed to there being a short-term upgrade to BPL and further exploration of options for rebuilding within the NHS or in collaboration with industry.

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Ministers asked to see whether there might be scope for further savings in the stop-gap measures as they were concerned that there might be no justification to incur short-term costs on upgrading if BPL was to be rebuilt.

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