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The goal of 275,000 donations for Factor 8 production had not been met a year after it had been given.

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Dr Maycock described that the Department of Health had been advised that the NBTS should reach the position of being able to supply the amount of concentrate from 275,000 donations by 1975, but this was clearly not possible.

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The DHSS and Dr Maycock understood that it was the supply of plasma for fractionation which needed to increase if the shortfall in meeting anticipated demand was to be met from within the NHS.

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The SHHD considered that the present dependence on commercial supplies of anti-haemophilic globulin concentrate and PPF posed a threat to the unpaid voluntary donor system.

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90% of the plasma production for Factor 8 concentrate had already been achieved.

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It was suggested that plasmapheresis should be practised more widely and rather more intensively than was currently being done.

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A number of regional transfusion centres had experienced an increase in demand for cryoprecipitate.

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The unpaid volunteers began donating by plasmapheresis at the North London Blood Transfusion Centre, Edgware.

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The number of regular attendees at the North London Blood Transfusion Centre, Edgware, exceeded 2,500 and over 80% of the donors attended for donation once a fortnight.

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It was recommended that SAG-M be introduced as soon as possible, and SAG-M and SAG-S were expected to yield a considerable increase in plasma.

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Dr Charles Rizza requested the purchase of Immuno Factor 8 concentrates at around £15,000 per year at the Oxford Haemophilia Centre.

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An article in The Lancet stated a preference for cryoprecipitate to concentrated human AHF.

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Dr Sheila Waiter attended a meeting with haemophilia centre directors where the capacity of fractionation facilities was discussed.

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The DHSS and the SHHD had agreed in principle to divert the plasma from south of the border to Liberton and the Factor 8 from this plasma would return to centres south of the border.

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Dr Rosemary Biggs's letter to the editor of The Lancet raising concerns about funding was published.

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A report of a new approach to the production of a concentrate of antihaemophilic globulin was prepared.

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Improved methods for the production of Factor 8 were published.

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Dr Rosemary Biggs, with the support of others, wrote a paper to press her case for higher figures of donations through a working party at the MRC. The paper also included references to the consumption of Factor 8 in the UK and the correlation between pool sizes and the risk of hepatitis.

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Concerns were raised at the Scottish National Blood Transfusion Service directors meeting about the over-insistence on concentrated red cells.

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Scottish National Blood Transfusion Service directors were of the opinion that plasmapheresis should not be introduced as a method of obtaining normal plasma at the time.

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