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In a memo from Michael O'Connor to Strachan Heppell, it was noted that the BPL project was a "shambles".

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Consideration began to be given to obtaining factor concentrate from Edinburgh, as there were capacity issues at BPL, but spare capacity at PFC.

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Although Northern Ireland was able to make cryoprecipitate from local blood donors, it was too small to produce factor concentrate itself.

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The quantity of NHS factor concentrate used in Northern Ireland increased dramatically once Northern Irish plasma began being sent to the BPL, as Factor 8 concentrate manufactured at Liberton was sent in return.

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Prescribing choices in England and Wales (being the choices that would be reflected in demand) were being formed when imported commercial Factor 8 filled the gap left by BPL's failure to supply, and this continued into the early 1980's.

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The increasing use of plasmapheresis for collection was pursued as it was a safer base material to manufacture concentrates due to the larger donation that was able to be extracted (the amount of plasma from one donation of whole blood was 40% of that from a donor of plasma by plasmapheresis).

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In Scotland, the national blood service defined self-sufficiency in blood products as the production of enough factor concentrate from a country's own resources to meet clinical need without the need for importation.

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At a meeting of the Blood Products Laboratory, it became clear that PFC's construction would cost more than the sum approved, and that despite a planned 1,500-litre capacity, it would initially only operate at 1,000 litres per week to reduce cost.

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It was estimated that 74 million international units of Factor 8 could be produced in the UK once the requirements for albumin were met.

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During this period, government funding was exceptionally constrained, inadequate and difficult to obtain for the redevelopment of BPL and the production of additional plasma for national self-sufficiency.

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Dr Angela Robinson was an enthusiast for plasmapheresis, and set up a pilot unit in Yorkshire.

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Dr Cumming was the regional transfusion director for Edinburgh and South East Scotland, a professional advocate for plasmapheresis, and was also one of the first three Scottish blood donors to reach 200 donations.

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In The Voluntary Blood Donor, Dr Cumming noted that the inadequacies that existed in modern developed countries were entirely the fault of the organisation of the service, and that forward planning was important for a successful voluntary blood donor system.

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In a Department of Health report, it was concluded that very few countries were capable of completely satisfying their blood needs (ie becoming self-sufficient) without acquiring a proportion of blood from paid donors.

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Lord Clarke in his oral evidence said that it was "daft" that he was being asked detailed questions about events of 40 years ago about something that was a tiny proportion of his activities.

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In his oral evidence, Lord Clarke said that he would reject any conclusion that there was a delay in the introduction of HIV screening.

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Lord Clarke in his oral evidence criticised the Inquiry as engaging in "historical research... with the elderly survivors, the ones that hadn't died so far, of those who are in the Department at the time, and in meticulous detail, which it's inconceivable that any witness could possibly remember."

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In response to a question about the line taken that there was no conclusive proof, Lord Clark in his evidence said, "We're not going to go long all day like this, are we? It doesn't -- I mean, doesn't this Inquiry wish to reach a conclusion? I don't know how many years you've been going. Extraordinary."

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Lord Clarke in his oral evidence to this inquiry agreed that emerging potential threats to public health need to be dealt with speedily.

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In his oral evidence Lord Clark said the former CMO Sir Henry Yellowlees was one of the officials, in all his many, many departments, one of the very senior and responsible officials who, shall he say, failed to impress him.

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