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It was recommended that SAG-M be introduced as soon as possible, and it was to be expected that it would yield a considerable increase in plasma which might be available to BPL for fractionation.

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Dr Lane recorded that it was in the last quarter of 1984 that plasma supplies to BPL increased as a result of SAG-M.

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Plasmapheresis first began in the United Kingdom in early 1967.

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The Joint Steering Committee on Blood Products Production thought that the use of plasmapheresis might be difficult to justify as a means to meet targets because it inevitably exposed donors to risk.

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The Central Committee for the National Blood Transfusion Service expressed the view that increased plasma supplies could be achieved either by increasing concentrated red cell use or by plasmapheresis.

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In a meeting between Dr Biggs and Dr Rizza, they explored the Factor 8 market and investigated the reasons for choosing one commercial brand over another.

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A DHSS minute recorded that it was not the intention to embark on a programme of plasmapheresis in England.

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The Scottish National Blood Transfusion Service Annual Report recorded that there was an increase of 82% in the number of units obtained by plasmapheresis of fresh frozen plasma. It seemed that Edinburgh, in particular, was using more plasmapheresis.

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The Code of Practice for the Clinical Use of Blood Cell Separators determined that a cardiac arrest team had to be available when machine plasmapheresis was used due to the risk of cardiac arrest occurring.

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Dr Robinson set up a pilot unit for plasmapheresis in Yorkshire in 1980.

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Dr Gunson stated that plasmapheresis should be addressed further and that centres with a 3-4 million population were ideally suited to that method of plasma collection.

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In Dr Gunson's notes on a visit to the Yorkshire RTC, he commented on the automated machines operating at the Yorkshire RTC spread across three sites, staffing and agreed targets.

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In a visitors note to the North East Thames RTC to discuss plasma supply, it was stated that Dr Harrison did not consider plasmapheresis to be an efficient way to collect plasma.

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In her written statement, Dr Harrison stated that recovered plasma was preferred to manual or machine plasmapheresis as it was much cheaper. It did not involve the cost of plasmapheresis equipment or static centres.

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In the transcript of Dr Lloyd's oral evidence he stated that the Newcastle RTC had a small plasmapheresis unit, but mostly plasma was recovered from whole blood donations.

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In his written statement, Dr Lloyd stated that the Newcastle RTC increased its plasma production for fractionation; the 1992/1993 plasma production figures, based on tonnes of plasma per million population, put the Newcastle Centre third behind the North London and Yorkshire centres.

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In the BPL and PFL Annual Report it was reported that plasmapheresis continued to grow as a source of plasma. In 1986/87 it gave rise to just over 10% of the plasma sent to BPL.

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In a memo from Dr Smith to Dr Lane, the possibility of small pool freeze-dried cryoprecipitate was discussed.

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The Chronological Presentation on the Domestic Supply of Blood Products in England and Wales held that expenditure for 1976/77 was set at £433,000 before cost adjustments, including revenue allocations.

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In a memo, it was noted that the Northern and West Midlands regions had not committed to providing plasma. The Northern region was offered increased capital, and the West Midlands region was offered an increased revenue allocation.

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