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A report of a new approach to the production of a concentrate of antihaemophilic globulin was prepared.

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Improved methods for the production of Factor 8 were published.

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Dr Rosemary Biggs, with the support of others, wrote a paper to press her case for higher figures of donations through a working party at the MRC. The paper also included references to the consumption of Factor 8 in the UK and the correlation between pool sizes and the risk of hepatitis.

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Concerns were raised at the Scottish National Blood Transfusion Service directors meeting about the over-insistence on concentrated red cells.

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Scottish National Blood Transfusion Service directors were of the opinion that plasmapheresis should not be introduced as a method of obtaining normal plasma at the time.

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Scottish National Blood Transfusion Service directors agreed that a system acceptable to both to BTS England and Wales and to SNBTS should be evolved in relation to the supply of plasma from England to PFC.

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In his evidence to the Penrose Inquiry, Dr Foster reflected that the decision to build a large plant for England and Wales and not to send plasma to Scotland on the basis of costs could be seen as wrong.

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Dr Katharine Dormandy pursued home therapy with cryoprecipitate, but it had its limitations due to the freezing facilities required.

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Cryoprecipitate was a valuable and preferred therapeutical material.

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The PFC had very substantial spare fractionation capacity and would have been able to assist England and Wales.

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The Aberdeen North East Scotland Blood Transfusion Service explained that the plan to increase the use of plasmapheresis would involve an increase in the amount of donations collected from the centre.

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A study in Scotland compared machine and manual plasmapheresis and reported the benefits of machine plasmapheresis.

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The Liberton Unit would be capable of receiving 1,500 litres of plasma per week at its commissioning time and, if necessary, up to 3,000 litres of plasma per week.

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The Policy Steering Group agreed that BPL would process all plasma for England and Wales and the PFC would process plasma for Northern Ireland and Scotland.

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In a letter from M Draper to Thomas McLean, it was noted that although the programme to secure plasma for the production of Factor 8 blood products was underway, an increase in plasma supply was not anticipated for some months and the situation was to be kept under review.

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In a memo from Dr Archibald McIntyre to Dr Bell, concern was noted that the growth of plasmapheresis might deter donors.

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The SHHD asked the DHSS when the Protein Fractionation Centre would be provided with English plasma for fractionation.

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During the closing submissions made on behalf of the DHHS and NHSBT to the Inquiry, emphasis was placed on the constrained financial position of the UK during the 1970s.

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During the closing submissions made on behalf of the DHSC to the Inquiry, some reasons for the delay in achieving in self-sufficiency included the withdrawal of the Lister Institute from the running of BPL, the constraints of the site BPL occupied, and the time it took to purchase land from the Lister Institute to enable expansion.

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During the closing submissions made on behalf of the NHSBT to the Inquiry, emphasis was placed on the constrained financial position of the UK during the 1970s.

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