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Dr Jones noted in a publication that all concentrates prepared from large donor pools carry a greater risk of serum hepatitis and possibly other disease transmission than cryoprecipitate. They should therefore be reserved for the treatment of severe haemophilia A in older children and adults.

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Dr Jones was critical of the World in Action documentary outlining that it presented a dramatised account of the danger of hepatitis which, by being taken out of context

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Newsletter from the Haemophilia Society Northern Branch illustrated the risks of jaundice, hepatitis B and hepatitis and made reference to concerns over large plasma pools and suggested that the associated dangers were not as much of a priority or concern for those responsible for the finance, organisation and development of these voluntary organisations, and by some members of the medical profession who continued to advocate the use of whole blood

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Dr Jones stated in a publication on home therapy that "The substantial improvements in the quality of life ... may be bought at the expense of shorter survival."

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The haemophilia centre at Cardiff moved in 1971 from Cardiff Royal Infirmary to University Hospital Wales

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The haemophilia centre at St Thomas' Hospital was under the directorship of Professor Ingram until 1979, when he was succeeded by Professor Geoffrey Savidge.

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In late 1972, Professor Bloom described the local supply of cryoprecipitate as "quite good", however that he would prefer to use freeze-dried concentrate if available.

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In 1976, Professor Bloom explained that while Cardiff used cryoprecipitate for ordinary bleeds, they needed freeze-dried material for the treatment of inhibitors and for home treatment.

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When considering Factor 8 supply, Professor Bloom had stopped using Armor product due to the hepatitis problem and he also no longer bought Immuno because the price was too high.

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Annual return from 1976 displaying the results of the treatment of Haemophilia A in Cardiff through the use of substantial quantities of cryoprecipitate, very modest amount of NHS concentrate, significant amounts of Kryobulin and Hemofil, as well as the use of small amounts of Factorate, Profilate and Koate.

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Annual return from 1977 showing that cryoprecipitate was used twice as much as commercial concentrate (primarily Hemofil) than NHS concentrate was used in Cardiff.

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Annual return regarding Cardiff Haemophilia Centre from 1978 showing that cryoprecipitate was used twice as much as commercial concentrate. Factorate was the largest in volume as well as substantial quantities of Koate and Hemofil also used.

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Annual return from 1979 showing that significant cryoprecipitate were still in use in the Cardiff Haemophilia Centre, but that over a million units of commercial concentrate was in use, compared with 328,538 units of NHS concentrate.

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In relation to the risks of hepatitis, Professor Bloom described to another clinician that a small percentage of these freeze dried preparations contained unavoidably the virus of serum hepatitis and therefore were potentially dangerous to the patient and their relatives.

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During the time that Professor Ludlam was working in Cardiff, he recalled Professor Bloom speaking about the Bournemouth hepatitis outbreak of 1974, making the Cardiff director cautious about US concentrates.

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The geographical area of the Royal Edinburgh Infirmary covered patients in the south of Fife, Kirkcaldy, Dunfermline and most of the Borders.

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During the 1970s, at the Edinburgh Royal Infirmary, the preferred choice of treatment of Dr Howard Davies was cryoprecipitate, with no commercial concentrates being used.

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When Dr Ludlam became director in 1980, his approach to treatment was the following: First, he not only made primary treatment from Haemophilia A became Factor 8 concentrate, but also increased the use of factor concentrates as a whole. Second, he increased the number of patients using home treatment.

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The effect of Professor Ludlam's introduction to factor concentrates was that the local blood transfusion service redirected donor blood plasma from cryoprecipitate production to concentrate manufacture.

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Towards the end of 1982, concerns arose as to the increased demand and limited supply of commercial treatment following the increase in home treatment. It was therefore necessary for more commercial product to be imported and Dr Ludlam agreed to keep up with the demand.

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