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Dr Craske and others published a journal article in The Lancet about an outbreak of Hepatitis A and B in patients with haemophilia in Bournemouth who had been given commercial factor 8 concentrate. He suggested that "commercial factor VIII concentrates should be reserved for the treatment of life-threatening bleeds in all haemophiliacs and for covering major operations".

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In oral evidence to the Inquiry Professor Gordon Lowe stated that the age of hospital transfer of children was "left very much to the haemophilia director at Yorkhill to decide...it was very much up to the children's director to decide...they would have a discussion with the adult centre and then often a joint review, usually at Yorkhill".

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Professor Gordon Lowe first heard NANBH being discussed at a conference in Glasgow in 1975 where Dr Craske (UKHCDO Hepatitis Working Party Chairman) was a speaker - "I remember him saying that it wasn't only hepatitis B, you could get hepatitis from non-A, non-B."

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Dr Craske gave a talk entitled Virus hepatitis complicating replacement therapy at the Symposium on Haemophilia.

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At a Haemophilia Reference Centre Directors meeting, Professor Edward Blackburn observed that "It seems that the Radio and Television authorities have the right to edit and comment on their presentations as they think fit."

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Dr Craske produced a report of the Haemophilia Directors Hepatitis Working Party, which presented evidence of specific protection conferred by a previous batch of Hemofil against contracting Non-A Non-B Hepatitis.

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In a Haemophilia Centre Directors' Hepatitis Working Party report, Dr Craske concluded that "there remains much work to be done to devise methods to prevent the threat of chronic liver disease clouding the undoubted benefits that large pool concentrates have brought."

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Dr Brian Colvin described in his oral evidence some clinicians' belief that Non-A Non-B Hepatitis was benign as "wishful thinking".

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Dr Brian Colvin confirmed that, by 1975, the haemophilia treating community was aware that there was at least a possibility of chronic liver disease in haemophilia.

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Dr Brian Colvin told the Inquiry he treated very small children with cryoprecipitate until the mid 1980s.

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Dr Brian Colvin told the Inquiry that around 1982-1983 he was using a significant quantity of commercial concentrate in the hospital due to shortfall in NHS concentrate.

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In a Haemophilia Centre Directors' Hepatitis Working Party meeting, Dr Kirk described the results of the prospective survey on hepatitis carried out at Edinburgh and Alton, which show a higher proportion of patients treated with freeze dried products who had consistently abnormal liver enzyme tests, compared with the boys treated with cryoprecipitate.

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In a Haemophilia Centre Directors' Hepatitis Working Party meeting, it was agreed that the NHS Factor 8 associated hepatitis study should start on 1 June 1978.

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Haemophilia centre directors agreed in principle that it was a good idea for patients to be kept on one type (or preferably one batch) of concentrate for long periods.

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Dr Craske requested haemophilia centre directors send in details of cases of chronic hepatitis on a new form which the Haemophilia Centre Directors' Working Party would draw up and distribute to centres.

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The reason for the DHSS' suggestion that patients be kept on one type or one batch of concentrate was to simplify analysis and presentation of results, increase the chances of identifying icterogenic material and permit the withdrawal of icterogenic bottles.

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Dr Craske wrote to the Small Grants Secretariat recording that whilst haemophilia centre directors had agreed in theory to maintaining patients on single batches or brands, the shortage of Factor VIII, large numbers of patients under treatment and the cost of maintaining stocks of Factor VIII meant that they did not consider it to be a practical policy to stick rigidly to this regime.

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Dr Mary Collins on behalf of the DHSS said regarding self-sufficiency that there was no limit on the amount of commercial material which Haemophilia Centres could receive.

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In a meeting of the haemophilia centre directors, it was reported that the 1976 and 1977 annual returns from haemophilia centres demonstrated that an increasingly large amount of commercial Factor 8 concentrate was being used by centres.

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The Hepatitis Working Party agreed to continue the study on the Oxford Haemophiliacs to obtain more evidence of the relationship of transaminitis and overt chronic liver disease to mortality.

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