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Dr Willoughby did not realise that commercial Factor VIII concentrates were exposing patients to the risk of viral infections until around 1983.

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Professor Ian Hann stated that 21 children at the RHSC were infected with HIV relatively early in the HIV crisis, "probably as a result of the widespread use of commercial product."

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Dr Geoffrey Tovey published a statement regarding the introduction of heat-treated concentrates into the Bristol Haemophilia Centre. His policy was to use NHS products in preference to commercial products and where there was a shortfall of NHS products, priority was given to children and adults known to be hepatitis and HIV negative.

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Dr Geoffrey Scott complained to Dr Geoffrey Tovey about the insolubility of the Elstree Factor 8 concentrate which meant it could no longer be used for home treatment and therefore more commercial Factor VIII would need to be purchased.

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In her written statement to the Inquiry, Dr Helena Daly stated that the Bristol Royal Infirmary instituted home therapy for children with severe haemophilia from the age of about four. Cryoprecipitate was seen as impractical for home therapy.

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Dr Geoffrey Scott wrote to a patient and his wife about another patient attending the Bristol Haemophilia Centre who recently died of AIDS and described the risk of contracting the disease by using imported blood products as extremely small.

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There were close links between the adult and paediatric treatment in Sheffield Children's Hospital, as well as a close relationship with the regional blood transfusion centre in Sheffield.

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Dr Lilleyman preferred to use cryoprecipitate for the treatment of children as it only exposed patients to a very small number of UK donors and therefore reduced the risk of viral transmission.

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It was the view at the Sheffield Children's' Hospital that cryoprecipitate was a safer blood product than factor concentrate.

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Cryoprecipitate remained in significant use at the Sheffield Childrens' Hospital, although concentrates (both NHS and commercial - but with increasing use of NHS over commercial) were also used. Annual Returns for Sheffield Children's Hospital Haemophilia suggest that cryoprecipitate was used for hospital treatment and that NHS concentrate was used for home treatment.

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Cryoprecipitate remained in significant use at the Sheffield Childrens' Hospital, although concentrates (both NHS and commercial - but with increasing use of NHS over commercial) were also used.

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Sheffield Children's Hospital used both cryoprecipitate and NHS concentrates. A small amount of Autoplex was used for the treatment of patients with inhibitors.

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Sheffield Children's Hospital mainly used cryoprecipitate and NHS Factor 8, with a small amount of Factorate. Autoplex was used for the treatment of patients with inhibitors.

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In 1984, NHS Factor Concentrate was the most used blood product provided by Sheffield Children's Hospital. Cryoprecipitate was also used.

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In 1985 cryoprecipitate and NHS concentrates were the main treatments provided at the Sheffield Children's Hospital. Autoplex was used for those with inhibitors, and a small amount of Hyate C (porcine Factor 8) was used.

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A paper was published which recorded the outcome of liver biopsies in five boys with severe haemophilia who had persistently abnormal liver function tests, Abnormal histology was present in all. It was concluded that cryoprecipitate should be used in preference to large pool Factor 8 concentrates in children with haemophilia.

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One child was infected with HIV at the Sheffield Children's' Hospital.

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Nicholas Calder was swapped from cryoprecipitate to factor VIII concentrate. His mother did not consent to the change and was never informed of the viral risk in the blood product. Nicholas was mostly treated with NHS concentrate but received commercial products several times.

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Rosemary Calder sought advice from Dr Cecil Reid about AIDS and was told to carry on with her son's home treatment as normal because the risk of contracting an infection was minimal.

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Ms Calder did not consent to a HIV test which confirmed her son was HIV positive at 11 years old. They were informed by a letter in the post.

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