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Study on clinical factors associated with progression to AIDS in an Italian Cohort of HIV-Positive haemophiliacs showed factor IX recipients were found to develop full-blown AIDS significantly earlier than factor VIII recipients.

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An estimate by the UK Haemophilia Doctors' Organisation suggested that around 360 children with bleeding disorders were infected with HIV as children in the UK.

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Haemophilia care in Liverpool had traditionally been divided between Alder Hey Children's Hospital and the Royal Liverpool Hospital, the patients graduating from one to the other in their mid teens.

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Dr Frank Boulton, in oral evidence, stated that somewhere between the ages of 14 and 18 a boy would transfer from Alder Hey to the Liverpool Royal Infirmary.

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The focus of Dr John Martin's work was paediatric oncology and he generally referred to himself as a consultant paediatrician or oncologist, rather than a haematologist.

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The 1977 Annual Returns for Alder Hey Children's Hospital recorded 643 packs of cryoprecipitate; in relation to concentrates, no figures were provided.

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The care of boys with haemophilia was shared between Dr Frank Boulton and Dr John Martin. They shared a regular integrated clinic at the Liverpool Royal Infirmary/Royal Liverpool Hospital. The haemostasis diagnostic laboratory at the LRI was Dr Frank Boulton's responsibility.

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Dr Martin, a consultant paediatrician, in a letter to BPL noted that they normally received their factor VIII via the adult centre at the Royal Liverpool Hospital.

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Dr Lynne Ball understood the position to be that products were supplied by the Royal Liverpool Adult Centre to Alder Hey.

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Dr Ball's recalled that, as a proportion of children registered per centre in the UK, Alder Hay "was one of the highest (if not the highest) proportion of HIV positive haemophiliacs."

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Data from UKHCDO suggested that 13 children were infected with HIV, a July 1987 report recorded 16 cases, and Dr Ball recollected approximately 12 boys who were HIV positive.

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By 1989, a large proportion of the clinical notes of children affected by HIV were missing essential treatment and decision-making details.

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There was no system of batch dedication to reduce donor exposure in Liverpool.

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Evidence confirmed that DDAVP was not in use until after 1988/89 in Liverpool. Dr Martin argued it was "of limited value, and difficult to use with small children."

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A report in July 1987 recorded 16 cases of children being infected at Alder Hey with HIV, though UKHCDO figures suggested 13 and Dr Ball recollected approximately 12.

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Annual Returns for Alder Hey Children's Hospital 1978 recorded the use of cryoprecipitate and both NHS and commercial concentrate.

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Annual Returns for Alder Hey Children's Hospital 1979 recorded the use of cryoprecipitate and both NHS and commercial concentrate.

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Annual Returns for Alder Hey Children's Hospital 1980 recorded the use of commercial concentrate (Factorate) increased.

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Annual Returns for Alder Hey Children's Hospital 1981 recorded Alder Hey treated its haemophilia patients almost exclusively with concentrate (both NHS and Factorate).

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Annual Returns for Alder Hey Children's Hospital 1982 recorded Alder Hey used almost exclusively concentrate, most of which was commercial.

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