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Fax from HM Customs and Excise to Dr Rejman regarding Recombinant VAT and Factor VIII.

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Kenneth Clarke stated the treatment of patients with recombinant Factor VIII, which contains human serum albumin as a stabiliser, was not without risk.

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Dr Metters made the point that recombinant had a risk, namely, that of being combined with albumin.

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Dr Rejman wrote: "there is no evidence that recombinant Factor VIII is any safer than plasma derived Factor VIII at the present time. You will be aware that recombinant Factor VIII contains plasma derived albumin as a carrier."

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Dr Savidge did not agree with Kenneth Clarke's comments concerning the comparative safety of the recombinant product.

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Dr Savidge's view on behalf of the Recombinant Factor VIII Users' Group was that the cheaper high purity plasma-derived Factor 8 was substantially contaminated by parvovirus B19. Recombinant Factor 8 was not.

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Dr Savidge stated that market trends in Europe, and North America showed that plasma derived Factor 8 was rapidly being phased out from clinical use in favour of recombinant.

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Draft briefing for an answer to a parliamentary question which arose in relation to the imposition of VAT on recombinant.

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Dr Rejman observed that "You will recall that in summary the Department feels that there is no justification for routine use of recombinant Factor VIII in patients with haemophilia".

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John Horam replied to Baxter Healthcare Limited regarding the imposition of VAT on recombinant.

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In a written answer to Parliament, Kenneth Clarke announced a revised leaflet "AIDS and how it concerns blood donors" was to be given individually to each donor or potential donor.

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DHSSNI accepted the recommendations of the second report of the Maycock Group, subject to a few reservations.

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Mary Sibellas wrote to Dr Geffen about the formation of an Advisory Group on Viral Hepatitis and suggested it should be a free-standing committee which would only meet occasionally but would be available to give advice if required.

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Dr Geffen submitted a paper to Dr Evans proposing the establishment of an advisory group on hepatitis.

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A meeting took place to discuss the setting up and terms of reference of an advisory group on viral hepatitis.

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Dr Geffen wrote to Dr Evans about the formation of an Advisory Group on Hepatitis.

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The terms of reference of the Advisory Group on Hepatitis were "To provide medical advice to the Chief Medical Officers of the Health Departments of the United Kingdom on all aspects of communicable hepatitis."

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The second meeting of the Advisory Group on Hepatitis took place.

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Dr John Holgate wrote to Stanley Godfrey about the safety of American Factor 8.

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The Observer published an article which suggested Factor 8 concentrates "may pose a grave threat to the health of haemophiliacs who inject it."

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